Rh(III)-catalyzed chelation-assisted intermolecular carbenoid functionalization of α-imino Csp(3)-H bonds

Chemical Communications : Chem Comm
Xun ChenWei Zeng

Abstract

A Rh(iii)-catalyzed cross-coupling/cyclization cascade of α-imino Csp(3)-H bonds with donor/acceptor α-acyl diazocarbonyl compounds has been developed. This novel transformation involves ligand-directed Csp(3)-H bond functionalization with carbenoids under the pyridine-chelation assistance, and offered an efficient access to synthetically versatile polysubstituted N-(2-pyridyl)pyrroles with a broad range of functional group tolerance.

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Citations

Jul 13, 2016·Chemical Communications : Chem Comm·Wei HouBing Zhou
Dec 31, 2016·Organic Letters·Ravindra S PhatakeChepuri V Ramana
Feb 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergio González-GrandaVicente Gotor-Fernández
Jan 5, 2021·The Journal of Organic Chemistry·Patrycja PaciorekAnna Jurowska
Oct 29, 2021·Chemical Communications : Chem Comm·Bin ZhuXiuling Cui

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