PMID: 11332157May 3, 2001Paper

Rhinocerebral zygomycosis in a patient with acute lymphoblastic leukemia

Annals of Oncology : Official Journal of the European Society for Medical Oncology
C LerchenmüllerW E Berdel

Abstract

We report a case of a 28-year-old man with acute lymphoblastic leukemia who developed rhinocerebral zygomycosis during induction chemotherapy. This life-threatening fungal infection is an infrequent cause of neutropenic fever, and is occasionally found in patients with leukemia and lymphoma, or patients with severely compromised defence mechanisms due to other diseases. It is caused by moulds belonging to the Mucoraceae family, and is characterized by local destruction of the affected organ. In our patient, the infection spread from the paranasal sinuses to the right orbit, destroyed intraorbital structures and resulted in blindness within days. Biopsy from the right maxillary sinus was performed and mucormycosis was suspected through microscopic examination. Culture of the resected specimen identified Rhizopus arrhizus as the causing agent. Treatment of zygomycosis should consist of radical surgical debridement of the infected tissue, together with intensive broad-spectrum antimycotic therapy with amphotericin B. What could be learned from this case is, that aggressive approaches to identify the cause of infection is necessary, and that aggressive treatment strategies are inevitable to overcome the infection. Furthermore, trea...Continue Reading

Citations

Feb 27, 2007·The Journal of Laryngology and Otology·H A Barrak
May 15, 2003·Hematology·Peter JacobsKen Esterhuizen

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