Rhinovirus inhibits antigen-specific T cell proliferation through an intercellular adhesion molecule-1-dependent mechanism

The Journal of Infectious Diseases
J E GernE C Dick

Abstract

To determine whether binding of human rhinovirus (HRV) to intracellular adhesion molecule-1 might disrupt airway immune processes, effects of a major HRV group, HRV-16, on T cell proliferation and cytotoxicity were defined. HRV (1-10 TCID50/cell) significantly inhibited T cell proliferation induced by antigen but not proliferation secondary to mitogens, interleukin-2, or an irradiated allogeneic T cell line. Noninfectious (UV-irradiated) HRV had similar effects. Inhibition of T cell proliferation was dependent on HRV binding to intercellular adhesion molecule-1 on monocytes, indicating that the virus interferes with lymphocyte activation indirectly through effects on antigen-presenting cells. In addition, HRV inhibited T cell cytotoxic responses but not NK cell activity. If these effects also occur in vivo, the resulting disturbance in local airway immunity could increase the chances of successful viral replication, and might also be a factor in the pathogenesis of secondary viral or bacterial respiratory tract infections.

Citations

Feb 4, 2003·Current Allergy and Asthma Reports·Nikolaos G Papadopoulos, Stelios Psarras
Aug 5, 2000·Allergy·E MicilloG F Abbate
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael G IsonMichael Boeckh
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·G FolkertsJ E Gern
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·K GrünbergP J Sterk
Oct 8, 1999·The Journal of Clinical Investigation·J StöcklW Knapp
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·S B DeitzK Kirkegaard
Nov 21, 2012·EMBO Molecular Medicine·Nathan W BartlettMichael R Edwards
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Ramses IlarrazaDarryl J Adamko
Mar 15, 2013·Journal of Theoretical Biology·Frederick R Adler, Peter S Kim
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N G PapadopoulosS L Johnston
Sep 23, 2014·The European Respiratory Journal·Brian G G OliverJudy Black
Oct 4, 2006·International Archives of Allergy and Immunology·Stefanie KirchbergerJohannes Stockl
Nov 1, 2003·American Journal of Respiratory Cell and Molecular Biology·Louis A RosenthalRobert F Lemanske
Jun 21, 2011·Immunological Reviews·Monica L GavalaJames E Gern
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K Grünberg, P J Sterk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.