Rhinovirus load and disease severity in children with lower respiratory tract infections

Journal of Medical Virology
Aya TakeyamaMitsuaki Hosoya

Abstract

It has not been clarified if there is a correlation between rhinovirus (RV) load and disease severity in the lower respiratory tract infections of hospitalized children. This study was undertaken to elucidate the contribution of the viral load to the development of disease severity in 412 children ≤3 years of age who were hospitalized with lower respiratory tract infections. The RV load in nasopharyngeal aspirates obtained from the patients at the time of admission was measured by real-time quantitative reverse-transcription polymerase chain reaction (PCR), and the clinical symptoms of the patients were assessed using a severity scoring system. Of the 412 patients, 43 (10.4%) were diagnosed with RV infections only, and 15 were determined to have high severity scores. When all patients infected with RV were assessed, there was no correlation between the viral load and the disease severity. However, there was a significant negative correlation between the disease severity and age among children <11 months of age (n = 15, ρ = -0.677, P = 0.006) and a significant positive correlation between the viral load and the disease severity among children ≥11 months of age (n = 28, ρ = 0.407, P = 0.032). Among the patients infected with RV <...Continue Reading

References

Feb 1, 1985·Journal of Applied Physiology·E R McFaddenJ Solway
Apr 13, 1999·The Journal of Allergy and Clinical Immunology·S M van SchaikR C Welliver
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·P M RenziS Spier
May 26, 1999·American Journal of Respiratory Cell and Molecular Biology·M K SchrothJ E Gern
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·J H AberleT Popow-Kraupp
Apr 27, 2000·The Pediatric Infectious Disease Journal·T JuvénO Ruuskanen
Jun 6, 2000·The Journal of Infectious Diseases·N G PapadopoulosS L Johnston
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Nikolaos G PapadopoulosDimitrios Kafetzis
Dec 18, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·James E GernRobert F Lemanske
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Anne Kotaniemi-SyrjänenMatti Korppi
Apr 12, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Robert F Lemanske
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Jan 13, 2004·Journal of Clinical Microbiology·Takashi EbiharaKunihiko Kobayashi
Jan 13, 2004·Reviews in Medical Virology·Frederick G Hayden
Nov 17, 2004·The Pediatric Infectious Disease Journal·Matti KorppiTiina M Reijonen
May 5, 2005·The Journal of Infectious Diseases·John P DeVincenzoAndrew J Bush
Jul 5, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·S A ScheltingaE C J Claas
Jul 16, 2005·Clinical Microbiology Reviews·Peter J M Openshaw, John S Tregoning
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Robert F LemanskeJames E Gern
May 30, 2006·The Pediatric Infectious Disease Journal·Tuomas JarttiOlli Ruuskanen
Oct 21, 2006·American Journal of Respiratory and Critical Care Medicine·Anne Marie SinghTina V Hartert
Mar 17, 2007·Scandinavian Journal of Infectious Diseases·Ju-Young ChungEung-Soo Hwang
Nov 7, 2007·The Pediatric Infectious Disease Journal·Daniel K L CheukSusan S Chiu
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Daniel J JacksonRobert F Lemanske
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Simon D MessageSebastian L Johnston
Dec 18, 2008·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Keiko Hamano-HasegawaUNKNOWN Acute Respiratory Diseases Study Group
Mar 5, 2009·The Pediatric Infectious Disease Journal·Janice K LouieDavid P Schnurr
Apr 9, 2010·Journal of Virology·James E Gern
May 18, 2010·The Journal of Allergy and Clinical Immunology·Ann C PalmenbergStephen B Liggett
Aug 17, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Angela AramburoW Lawrence Drew
Jan 29, 2011·The Journal of Allergy and Clinical Immunology·E Kathryn MillerTina V Hartert
Oct 21, 2011·The Journal of Infectious Diseases·Marika K IwaneDean D Erdman

❮ Previous
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Citations

Jan 9, 2013·Clinical Microbiology Reviews·Samantha E JacobsThomas J Walsh
Jul 31, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S EspositoN Principi
Mar 19, 2014·The Journal of Allergy and Clinical Immunology·Kazuyuki NakagomeJames E Gern
Feb 26, 2016·Journal of the Pediatric Infectious Diseases Society·Helen Y ChuEileen J Klein
Mar 22, 2014·Journal of Clinical Laboratory Analysis·Jeffrey M BenderElizabeth M Marlowe
Apr 5, 2015·The Journal of Allergy and Clinical Immunology·Tuomas JarttiCarlos A Camargo
Jan 21, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Seong-Ho ChoiHeungsup Sung
Mar 3, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Juan AmbrosioniLaurent Kaiser
Dec 9, 2014·Journal of Virological Methods·Young Ran NamChul Hyun Joo
Oct 17, 2016·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Cristina CalvoUNKNOWN Grupo de Estudio de Sibilancias Recurrentes
Mar 25, 2017·Critical Reviews in Microbiology·Lisa BillardSophie Vallet
Jun 26, 2017·The Journal of Infection·Simon B DrysdaleOctavio Ramilo
Feb 1, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kim Tien NgKok Keng Tee
Jul 11, 2013·The Pediatric Infectious Disease Journal·Olli RuuskanenOctavio Ramilo
Feb 25, 2014·Expert Review of Anti-infective Therapy·Nicola PrincipiSusanna Esposito
Jul 1, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Annamari KoistinenTuomas Jartti
Mar 7, 2021·Viruses·Maria I Sanchez-CodezAsuncion Mejias
Mar 7, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anthony ComteCatherine Manoha
Dec 12, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alpana WaghmareWendy M Leisenring

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