PMID: 806533Jul 1, 1975

Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States

Infection and Immunity
W BurgdorferL A Thomas

Abstract

A rickettsia related to but distinct from the spotted fever agent, Rickettsia rickettsii, has been detected in 167 (18.9%) of 884 Rhipicephalus sanguineus taken off dogs in central and northern Mississippi. The organisms could readily be isolated in male meadow voles (Microtus pennsylvanicus), where it produced massive infections in the tissues of tunica vaginalis. It was practically nonpathogenic for male guinea pigs, although inoculation of these animals with infected tunica vaginalis of voles afforded in 30 of 38 instances solid immunity to challenge with virulent R. rickettsii. The Rhipicephalus rickettsia grew well in monolayers of chicken embryo fibroblast, Vero, mouse L, and HeLa cells. Cytopathogenic effects were minimal unless large concentrations of rickettsiae were used as inocula. It also could be established in embryonated hen eggs but only after injection of massive doses of L cell-propagated organisms. Serological tests (complement fixation, microagglutination and/or micro immunofluorescence) indicated that the newly described Rickettsia belongs to the spotted fever group but differs from R. rickettsii, R. akari, and R. conorii. Antigenic differences were also demonstrated by direct fluorescence microscopy as wel...Continue Reading

Citations

Mar 5, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher D PaddockChristopher A Ohl
Aug 4, 2006·Applied and Environmental Microbiology·Marina E EremeevaGregory A Dasch
Jun 23, 2009·Annals of the New York Academy of Sciences·Christopher D Paddock
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Sep 20, 2001·Revista Da Sociedade Brasileira De Medicina Tropical·F de F Fernandes, E de P Freitas
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Related Concepts

Antigens, Bacterial
Bacterial Vaccines
Bacteriological Techniques
Centrifugation, Density Gradient
Chick Embryo
Ondatra
Disease Vectors
Immunofluorescence Assay
Cavia porcellus
Hemolymph

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