Rhizomes of Gastrodia elata B(L) possess antidepressant-like effect via monoamine modulation in subchronic animal model

The American Journal of Chinese Medicine
Pei-Ju ChenLee-Yan Sheen

Abstract

Depression is one of the most common psychiatric disorders that affects over 10% of individuals. However there is no desirable therapeutic approach nowadays. Thus, looking for an alternative treatment is important. The objectives of this study are to investigate the antidepressant effects of the rhizomes of Gastradia elata B(L), a traditional Chinese medicine, in the animal model forced-swimming test (FST), and to analyze the monoamine content in the rats' brain regions in order to better understand the possible mechanisms of the water extract of the rhizomes of Gastrodia elata B(L) (WGE). Subchronic administration of 0.5 or 1.0 mg/kg bw WGE by gavage for 21 consecutive days significantly reduced the immobility duration of rats in the test session of FST as compared to the control group (p < 0.05), with the equivalent effects as the antidepressant drug fluoxetine. The concentration of serotonin (5-HT) in the frontal cortex and dopamine (DA) in striatum were significantly increased after WGE administration (p < 0.05). The ratio of 5-HIAA/5-HT and (DOPAC + HVA)/DA, i.e. the turnover of 5-HT and DA respectively, were also significantly lowered in WGE groups (p < 0.05). In summary, the present study showed that the WGE possesses an...Continue Reading

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Citations

Feb 8, 2011·Journal of Biomolecular Structure & Dynamics·Tung-Ti ChangCalvin Yu-Chian Chen
Nov 3, 2015·Asian Pacific Journal of Tropical Medicine·Samrat BaralJungwon Seo
Sep 20, 2011·Journal of Ethnopharmacology·Chung-Fen TsaiNai-Kuei Huang
Jul 21, 2010·Journal of Pharmacological Sciences·Eun-Joo ShinHyoung-Chun Kim
Jul 6, 2016·Journal of Ethnopharmacology·Hong-Dan ZhanTing-Liang Jiang
Jun 9, 2019·Natural Products and Bioprospecting·Si-Yue ChenJi-Jun Chen
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