Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells.

Journal of Cell Science
Hiyori AbikoKensaku Mizuno

Abstract

Cyclic stretch is an artificial model of mechanical force loading, which induces the reorientation of vascular endothelial cells and their stress fibers in a direction perpendicular to the stretch axis. Rho family GTPases are crucial for cyclic-stretch-induced endothelial cell reorientation; however, the mechanism underlying stretch-induced activation of Rho family GTPases is unknown. A screen of short hairpin RNAs targeting 63 Rho guanine nucleotide exchange factors (Rho-GEFs) revealed that at least 11 Rho-GEFs – Abr, alsin, ARHGEF10, Bcr, GEF-H1 (also known as ARHGEF2), LARG (also known as ARHGEF12), p190RhoGEF (also known as ARHGEF28), PLEKHG1, P-REX2, Solo (also known as ARHGEF40) and α-PIX (also known as ARHGEF6) – which specifically or broadly target RhoA, Rac1 and/or Cdc42, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells. Overexpression of Solo induced RhoA activation and F-actin accumulation at cell-cell and cell-substrate adhesion sites. Knockdown of Solo suppressed cyclic-stretch- or tensile-force-induced RhoA activation. Moreover, knockdown of Solo significantly reduced cyclic-stretch-induced perpendicular reorientation of endothelial cells when cells were cultured at high dens...Continue Reading

References

May 1, 1989·Basic Research in Cardiology·P C Dartsch, E Betz
Mar 23, 2002·Science·Thijn R BrummelkampReuven Agami
Jul 9, 2002·Genes & Development·Anja Schmidt, Alan Hall
Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Kent L RossmanJohn Sondek
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roland KaunasShu Chien
Oct 22, 2008·Microvascular Research·Konstantin G Birukov
Jan 31, 2009·Science·Armando del RioMichael P Sheetz
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Benjamin GeigerAlexander D Bershadsky
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Michele A Wozniak, Christopher S Chen
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Cornelia Hahn, Martin A Schwartz
Jun 16, 2009·Current Opinion in Cell Biology·Alok Tomar, David D Schlaepfer
Jan 1, 2010·Human Molecular Genetics·Tomonaga MatsushitaMichiaki Kubo
May 11, 2010·Nature Cell Biology·Shigenobu YonemuraMai Shibata
Sep 21, 2010·Biochemical and Biophysical Research Communications·Chin-Fu LeeRoland Kaunas
Apr 22, 2011·Nature Reviews. Molecular Cell Biology·Christopher C DuFortValerie M Weaver
May 17, 2011·Nature Cell Biology·Christophe GuilluyKeith Burridge
Jan 1, 2010·The Open Biomedical Engineering Journal·Y UekiM Sato
Jul 17, 2012·Journal of Cell Science·Ulrich S Schwarz, Margaret L Gardel
Jul 17, 2012·Journal of Cell Science·Pere Roca-CusachsMichael P Sheetz
Aug 31, 2012·Biochemistry·Elizabeth C LesseyKeith Burridge
Mar 26, 2013·Journal of Cell Science·Stephan Huveneers, Johan de Rooij
May 21, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brian C DipaoloSusan S Margulies
Jun 21, 2013·Open Biology·Tea Vallenius

❮ Previous
Next ❯

Citations

Jan 13, 2016·Human Molecular Genetics·Mukesh GautamP Hande Özdinler
Oct 17, 2015·Vascular Pharmacology·Ricardo Hernández-GarcíaJosé Vázquez-Prado
Jan 30, 2016·Molecular Biology of the Cell·Sachiko FujiwaraKensaku Mizuno
Jul 27, 2015·Biochimica Et Biophysica Acta·Eric Boucher, Craig A Mandato
Aug 11, 2016·Cellular and Molecular Life Sciences : CMLS·Yvonne L Dorland, Stephan Huveneers
Oct 21, 2016·Journal of Cutaneous and Aesthetic Surgery·Shaun S TanWarren Rozen
Apr 28, 2017·Small GTPases·Satoshi ShibataShinobu Inagaki
May 24, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Sophie Chagnon-LessardAndrew E Pelling
Jul 18, 2017·Development, Growth & Differentiation·Shota P FukudaShinji Deguchi
May 2, 2018·Cell Structure and Function·Ryosuke NishimuraKensaku Mizuno
Sep 13, 2017·Cold Spring Harbor Perspectives in Biology·Vania Braga
Jan 9, 2019·Annals of the New York Academy of Sciences·Loes C A Rutten-Jacobs, Natalia S Rost
Feb 20, 2019·Integrative Biology : Quantitative Biosciences From Nano to Macro·Sophie Chagnon-LessardAndrew E Pelling
Apr 1, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Sachiko FujiwaraShinji Deguchi
Jun 16, 2019·Journal of Biomechanical Engineering·Daisuke Yoshino, Masaaki Sato
Dec 17, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ting WangStephen M Black
Dec 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Stefan MüllerYoshihiro Ito
Jan 20, 2019·Neurology·Myriam Fornage, Ashley H Beecham
Jan 20, 2019·Neurology·Matthew TraylorUNKNOWN International Stroke Genetics Consortium
Sep 17, 2020·Clinical Science·Yoshito Yamashiro, Hiromi Yanagisawa
Jan 14, 2017·Journal of Biochemistry·Kazumasa OhashiKensaku Mizuno
Jun 11, 2020·International Journal of Molecular Sciences·Wei-Hsuan WangHsueh-Fen Juan
May 21, 2016·Journal of Cell Science·Spencer A FreemanCalvin D Roskelley
Jun 17, 2018·Physical Review. E·Chika OkimuraYoshiaki Iwadate
Jul 22, 2018·Investigative Ophthalmology & Visual Science·Ying YuanBilian Ke
Apr 6, 2019·The Journal of Cell Biology·Vanessa V JuettnerAsrar B Malik
Apr 24, 2018·Nucleic Acids Research·Roopali PradhanKundan Sengupta
Dec 15, 2020·Journal of Cell Science·Komaki NinomiyaKazumasa Ohashi
May 6, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alamzeb KhanRichard W Pierce
Aug 26, 2021·Journal of Cell Science·Komaki NinomiyaKazumasa Ohashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.