PMID: 16515473Mar 7, 2006Paper

Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma

Mini Reviews in Medicinal Chemistry
Reinoud GosensAndrew J Halayko

Abstract

In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesn't inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.

Citations

Apr 7, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xinxin CiXuming Deng
Nov 20, 2013·Current Opinion in Pulmonary Medicine·Maria L DowellRamaswamy Krishnan
Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·Jeanette P BrownRaul M Torres
Aug 1, 2009·American Journal of Respiratory and Critical Care Medicine·Yoshihiko ChibaMiwa Misawa
Feb 14, 2009·American Journal of Respiratory Cell and Molecular Biology·Y S PrakashChristina M Pabelick
Aug 9, 2008·American Journal of Respiratory Cell and Molecular Biology·Yoshihiko ChibaMiwa Misawa
Feb 10, 2009·American Journal of Respiratory Cell and Molecular Biology·Yoshihiko ChibaMiwa Misawa
Feb 14, 2009·American Journal of Respiratory Cell and Molecular Biology·Bart G J DekkersHerman Meurs
May 11, 2006·Respiratory Research·Reinoud GosensAndrew J Halayko
Feb 4, 2014·Respiratory Physiology & Neurobiology·Vanessa R SilvaAna Paula L de Oliveira
Nov 10, 2009·Canadian Journal of Physiology and Pharmacology·Andrew J Halayko, Saeid Ghavami
Oct 4, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko ChibaMiwa Misawa
Feb 24, 2009·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Motohiko HanazakiMiwa Misawa
Jan 23, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko ChibaMiwa Misawa
Apr 13, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko ChibaMiwa Misawa
Sep 23, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko ChibaMiwa Misawa
Oct 24, 2012·Pharmacology & Therapeutics·Bart G J DekkersMartina Schmidt
Jul 31, 2012·Pulmonary Pharmacology & Therapeutics·Herman MeursReinoud Gosens
Oct 20, 2009·Bioorganic & Medicinal Chemistry Letters·Yan YinYangbo Feng
Dec 16, 2006·European Journal of Pharmacology·Dae Yong KimJai Youl Ro
Dec 13, 2006·British Journal of Pharmacology·D SchaafsmaS A Nelemans
Aug 19, 2010·Journal of Cellular and Molecular Medicine·Sara S RoscioniMartina Schmidt
Oct 22, 2015·Journal of Medicinal Chemistry·Yangbo FengRongshi Li
May 4, 2013·Current Opinion in Pharmacology·William T GerthofferBlanca Camoretti-Mercado
Apr 16, 2008·European Journal of Pharmacology·Dedmer SchaafsmaHerman Meurs
Oct 16, 2010·Journal of Pharmacological Sciences·Yoshihiko ChibaMiwa Misawa
Apr 27, 2016·Pharmacology & Therapeutics·Tonio Pera, Raymond B Penn
Oct 28, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yoshihiko ChibaMiwa Misawa
Jul 17, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kuldeep KumawatReinoud Gosens
Jul 17, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kaiyu YuanMajd Zayzafoon
Feb 26, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yoshihiko ChibaMiwa Misawa
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dedmer SchaafsmaHerman Meurs
May 23, 2012·Pharmacological Reviews·Mario CazzolaM Gabriella Matera
Oct 7, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yoshihiko ChibaHiroyasu Sakai
Feb 6, 2020·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Fumitake Usui-KawanishiRyuji Inoue
Sep 1, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yoshihiko ChibaMiwa Misawa
Apr 27, 2007·American Journal of Physiology. Cell Physiology·Dedmer SchaafsmaHerman Meurs
May 10, 2017·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Hiroyasu SakaiYoshihiko Chiba
Jul 11, 2006·Cellular Signalling·Deepak A Deshpande, Raymond B Penn

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