Rho Kinases in Autoimmune Diseases

Annual Review of Medicine
Alessandra B PernisWoelsung Yi

Abstract

The Rho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key downstream effectors for Rho GTPases. The ROCKs are increasingly recognized as critical coordinators of a tissue response to injury due to their ability to modulate a wide range of biological processes. Dysregulated ROCK activity has been implicated in several human pathophysiological conditions ranging from cardiovascular and renal disorders to fibrotic diseases. In recent years, an important role for the ROCKs in the regulation of immune responses is also being uncovered. We provide an overview of the role of the ROCKs in immune cells and discuss studies that highlight the emerging involvement of this family of kinases in the pathogenesis of autoimmune diseases. Given the potential promise of the ROCKs as therapeutic targets, we also outline the approaches that could be employed to inhibit the ROCKs in autoimmune disorders.

References

Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M KobayashiY Komada
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miguel Vicente-ManzanaresFrancisco Sánchez-Madrid
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li LiuJohn M Harlan
Feb 8, 2003·The Journal of Biological Chemistry·Rebecca A Worthylake, Keith Burridge
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pierre-Louis TharauxThomas M Coffman
Oct 14, 2003·International Immunopharmacology·Masayuki AiharaMasatomo Mori
Nov 25, 2003·Journal of Leukocyte Biology·Henk HoningHelga E de Vries
May 3, 2005·Nature Reviews. Drug Discovery·Bernhard K MuellerNicole Teusch
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Aron B Jaffe, Alan Hall
Apr 1, 2006·The Journal of Biological Chemistry·Toru TanakaYasuo Hamamori
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yansong LiGeorge C Tsokos
Aug 7, 2007·Nature Immunology·Anne BrüstleMichael Lohoff
Jan 4, 2008·Investigative Ophthalmology & Visual Science·Jian ChenNirmala SundarRaj
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lena SchifferAnne Davidson
Apr 26, 2008·European Journal of Cell Biology·Stéphane OryAnne Blangy
Sep 2, 2008·Arthritis and Rheumatism·Dominik R HaudenschildMartin K Lotz
Dec 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chirag B KhatiwalaAndrew J Putnam
Jan 27, 2009·Atherosclerosis·Anju NohriaPeter Ganz
Jun 6, 2009·Journal of Internal Medicine·A B Pernis
Aug 22, 2009·Nature Reviews. Immunology·Victor L J Tybulewicz, Robert B Henderson
Oct 14, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·C Thomas G AppletonFrank Beier
Nov 13, 2009·Cellular and Molecular Life Sciences : CMLS·C Hahmann, T Schroeter
Dec 30, 2009·Arthritis and Rheumatism·Dominik R HaudenschildDarryl D D'Lima
Jul 2, 2010·Current Opinion in Rheumatology·José C Crispín, George C Tsokos
Aug 11, 2010·The Journal of Clinical Investigation·Partha S BiswasAlessandra B Pernis
Aug 31, 2010·Cytoskeleton·Mutsuki AmanoKozo Kaibuchi
Nov 11, 2010·Journal of Hypertension·Takaki HataUNKNOWN ROCK Study Group
Nov 16, 2010·Current Opinion in Nephrology and Hypertension·Radko Komers
Nov 30, 2010·Cellular Immunology·Partha S BiswasAlessandra B Pernis
Feb 15, 2011·Arthritis Research & Therapy·Mary K Crow
May 11, 2011·Bone·R Graham G Russell
May 14, 2011·The European Respiratory Journal·M ZhuJ K Liao
Jun 21, 2011·Small GTPases·Sarah J Heasman, Anne J Ridley
Jul 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia F SorianoJens V Stein
Aug 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xin ZhangSilva Markovic-Plese
Sep 3, 2011·Current Opinion in Rheumatology·L van BonT R D J Radstake
Oct 26, 2011·Nature Reviews. Rheumatology·Swati BhattacharyyaJohn Varga
Oct 29, 2011·Stroke; a Journal of Cerebral Circulation·David A McDonaldIssam A Awad

❮ Previous
Next ❯

Citations

Mar 12, 2017·Annals of the Rheumatic Diseases·Cristina RozoAlessandra B Pernis
Oct 28, 2016·F1000Research·Edd RickerAlessandra B Pernis
Jul 20, 2019·Cells·Matthias BrosStephan Grabbe
Jun 6, 2018·Frontiers in Immunology·Takayuki KatsuyamaVaishali R Moulton
Dec 6, 2017·Current Opinion in Rheumatology·Mindy S Lo, George C Tsokos
Mar 24, 2020·PLoS Biology·Candelas Álvarez-SalameroMaría N Navarro
Apr 2, 2020·The Journal of Clinical Investigation·Edd RickerAlessandra B Pernis
Sep 11, 2020·Cells·Gloria Pastor-FernándezMaría N Navarro
Jan 16, 2021·Clinical Reviews in Allergy & Immunology·Ming ZhaoQianjin Lu
Jun 18, 2021·Small GTPases·Clara SteichenNicolas Bourmeyster
Aug 18, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Alexandra Zanin-Zhorov, Bruce R Blazar

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
nuclear translocation
dissection
biopsies

Software Mentioned

SurfaceLogix

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Brucellosis (ASM)

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Risk Reduction

Prevention of cardiovascular disease is an important health initiative. Risk reduction including physical activity, smoking cessation, diet, blood pressure lowering drugs and pharmacotherapy. Here is the latest research on cardiovascular risk reduction.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Brucellosis

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

The International Journal of Biochemistry & Cell Biology
Almudena Pacheco, Jonathan Chernoff
The Journal of Sexual Medicine
Serap GurWayne J G Hellstrom
Current Opinion in Nephrology and Hypertension
Radko Komers
© 2022 Meta ULC. All rights reserved