Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe(3+) in Cancer Stem Cells

ACS Applied Materials & Interfaces
Ruihua GuoNicolas H Voelcker

Abstract

A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe(3+) detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 μM are demonstrated as a Fe(3+) turn-on fluorescent nanosensor in cancer stem cells. Fe(3+) binding to such GQDs (RBD-GQDs-Fe(3+)) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.

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Citations

Jul 30, 2016·ACS Applied Materials & Interfaces·Ankan Dutta Chowdhury, Ruey-An Doong
Sep 7, 2019·Sensors·Nur Ain Asyiqin AnasSilvan Saleviter
Jul 8, 2020·Chemical Society Reviews·Jiyou HanJong Seung Kim
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Oct 20, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Siyu LeiHaitao Wang
Jun 12, 2021·Journal of Fluorescence·Nima Ambika MadhusoodananSubodh Ganesanpotti
Jul 3, 2021·Cancers·Daniela IannazzoGiovanni Neri
Jun 12, 2018·ACS Applied Materials & Interfaces·Bo NiuLei Jiang
Feb 6, 2020·The Journal of Physical Chemistry Letters·Wen SuLouzhen Fan
May 6, 2019·ACS Applied Materials & Interfaces·Pavithra V RaviPraveen Govindh

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