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Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains

ACS Chemical Neuroscience

May 18, 2011

Masahiro OnoHideo Saji

Abstract

A novel series of rhodanin (RH) and thiohydantoin (TH) derivatives were designed and synthesized for detecting tau pathology in the brains of patients with Alzheimer's disease (AD). In experiments in vitro using tau and β-amyloid (Aβ) aggregates, the TH derivative, TH2, showed high spec...read more

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Tauopathies
Derivatives
APP protein, human
Positron-Emission Tomography
Neurofibrillary Degeneration (Morphologic Abnormality)
Proteins, Recombinant DNA
Brain
Uptake
Thiohydantoins
17
Paper Details
References
  • References29
  • Citations22
123
  • References29
  • Citations22
123

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Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains

ACS Chemical Neuroscience

May 18, 2011

Masahiro OnoHideo Saji

PMID: 22778869

DOI: 10.1021/cn200002t

Abstract

A novel series of rhodanin (RH) and thiohydantoin (TH) derivatives were designed and synthesized for detecting tau pathology in the brains of patients with Alzheimer's disease (AD). In experiments in vitro using tau and β-amyloid (Aβ) aggregates, the TH derivative, TH2, showed high spec...read more

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Tauopathies
Derivatives
APP protein, human
Positron-Emission Tomography
Neurofibrillary Degeneration (Morphologic Abnormality)
Proteins, Recombinant DNA
Brain
Uptake
Thiohydantoins
17

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References29
  • Citations22
123
  • References29
  • Citations22
123
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