Rhodiola-induced inhibition of adipogenesis involves antioxidant enzyme response associated with pentose phosphate pathway

Phytotherapy Research : PTR
Ok-Hwan LeeYoung-Cheul Kim

Abstract

The aim of this study was to investigate whether Rhodiola crenulata extract and tyrosol, a major bioactive phenolic compound present in Rhodiola, change the activities of endogenous antioxidant enzyme response (AER) and energy pathways linked to proline-mediated pentose phosphate pathway (PPP) during adipogenesis. Treatment with Rhodiola extracts inhibited the activities of proline dehydrogenase (PDH) and glucose-6-phosphate dehydrogenase (G6PDH) as well as lipid accumulation and reactive oxygen species (ROS) production. The inhibition of PDH and G6PDH activities by Rhodiola likely prevented proline oxidation required for critical ATP generation that is coupled to AER via the PPP, leading to inhibition of adipogenesis. Rhodiola extracts dose-dependently increased superoxide dismutase (SOD) activity, resulting in a reduced ROS level during adipogenesis. Moreover, the effects of tyrosol, a major bioactive compound in Rhodiola species, were directly correlated with all observed effects by Rhodiola extracts. These results indicate that the antiadipogenic effects of Rhodiola extracts can be attributed to a phenolic tyrosol that may potentially disrupt proline-mediated energy generation and AER via PPP, resulting in the suppression o...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E M KowaloffS J Downing
Jan 1, 1984·Methods in Enzymology·L W Oberley, D R Spitz
Apr 6, 1995·Biochemical and Biophysical Research Communications·P P SaradhiK V Prasad
Feb 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R F KletzienL A Foellmi
Nov 24, 1999·Free Radical Biology & Medicine·A P Arrigo
Dec 10, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A PanossianH Wagner
Jan 12, 2000·Molecular and Cellular Biochemistry·H CabezasE Meléndez-Hevia
Mar 10, 2001·Cell·B M Spiegelman, J S Flier
May 26, 2001·Annual Review of Nutrition·L M Salati, B Amir-Ahmady
Aug 21, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S O Olusi
Oct 4, 2002·Nutrition·Yun-Zhong FangGuoyao Wu
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·John F KeaneyUNKNOWN Framingham Study
May 16, 2003·Phytotherapy Research : PTR·Midori Mori, Noboru Hasegawa
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Apr 15, 2004·Free Radical Biology & Medicine·Antonio Valencia, Julio Morán
Oct 12, 2004·The Journal of Pharmacology and Experimental Therapeutics·Georg T WondrakElaine L Jacobson
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Feb 10, 2006·The Journal of Biological Chemistry·Jeffrey M BlumbergAnthony N Hollenberg
Nov 27, 2007·Free Radical Biology & Medicine·Navasona KrishnanDonald F Becker

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Citations

Oct 22, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young-Jun LeeOk-Hwan Lee
Apr 3, 2014·BioFactors·Monica Colitti, Stefano Grasso
May 18, 2016·BMC Complementary and Alternative Medicine·Kuen-Tze LinShih-Yu Lee
Sep 23, 2014·BMC Complementary and Alternative Medicine·Ramakanta LamichhaneHyun-Ju Jung
Feb 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liwei SunYujun Liu
May 15, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena PomariMonica Colitti
Mar 28, 2018·Gut Pathogens·Khachik E LabachyanMahtab Jafari
Jun 5, 2020·Lasers in Surgery and Medicine·Andrew McCollochMichael Cho
Nov 9, 2017·International Journal of Molecular Medicine·Sun-Il ChoiOk-Hwan Lee
Nov 2, 2011·International Journal of Food Sciences and Nutrition·Shun-Wan Chan
Apr 18, 2014·Molecular and Cellular Biochemistry·Sabrina KrautbauerChrista Buechler
Sep 1, 2015·Journal of Food and Drug Analysis·Hsiu-Mei ChiangKuo-Ching Wen
Nov 9, 2017·Molecular Medicine Reports·Xiaoming ShiBonan Lv
Dec 31, 2020·Oxidative Medicine and Cellular Longevity·Francesca PacificiDavid Della-Morte
May 26, 2021·Journal of Chromatography. a·Hanna NikolaichukIrena Maria Choma

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