Rhodium-catalyzed asymmetric synthesis of indanones: development of a new "axially chiral" bisphosphine ligand

Journal of the American Chemical Society
Ryo ShintaniTamio Hayashi

Abstract

A rhodium-catalyzed asymmetric isomerization of racemic alpha-arylpropargyl alcohols to beta-chiral indanones has been developed. High enantioselectivity has been realized by the use of a newly developed axially chiral bisphosphine ligand. This ligand is unique in the sense that its axial chirality is fixed to a single configuration upon complexation to a transition metal due to other chiral axes existing within the same molecule.

References

Jan 6, 2004·Angewandte Chemie·Séverine JeulinPhilippe Dellis
Mar 10, 2005·Journal of the American Chemical Society·Hokuto YamabeNobuharu Iwasawa

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Citations

Jan 21, 2016·Chemistry : a European Journal·Bartolo GabrieleLucia Veltri
Jun 8, 2018·Chemistry : a European Journal·Kui Fun LeeGuochen Jia
Mar 13, 2014·Chemistry : a European Journal·Haizhu YuZhi-Min Dang
Jul 5, 2007·Organic & Biomolecular Chemistry·Kazunori Tsubaki
Jan 12, 2008·Angewandte Chemie·Ryo ShintaniTamio Hayashi
Apr 5, 2007·Angewandte Chemie·Ryo ShintaniTamio Hayashi
Jun 27, 2012·Organic & Biomolecular Chemistry·Hajar el HajjoujiFernando López Ortiz
Apr 7, 2017·Beilstein Journal of Organic Chemistry·Marika TurekPiotr Bałczewski
Sep 21, 2011·Chemistry : a European Journal·Yuta SuzukiMasakatsu Shibasaki
Oct 24, 2012·Chemical Communications : Chem Comm·Mamoru TobisuNaoto Chatani
Dec 11, 2013·Organic & Biomolecular Chemistry·Alexey N ButkevichJanine Cossy
Apr 14, 2015·Angewandte Chemie·Guizhou YueJianrong Steve Zhou
Oct 31, 2007·The Journal of Organic Chemistry·Ana MinattiStephen L Buchwald
Apr 19, 2007·Chemical Reviews·Clara I HerreríasChao-Jun Li
Jul 25, 2019·Organic Letters·Xurong QinJianrong Steve Zhou

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