Rhodium-catalyzed C-H bond activation alkylation and cyclization of 2-arylquinazolin-4-ones

Organic & Biomolecular Chemistry
Minhao LouYiyuan Peng

Abstract

An efficient method for the synthesis of isoquinolino[1,2-b]quinazolin-8-one derivatives and 12-methyl-12H-isoindolo[1,2-b]quinazoline-10-one derivatives is described herein. With rhodium catalysis, the desired products are obtained through a sequence reaction of C-H activation-based alkenylation and intramolecular aza-Heck-type cyclization. The developed method has a wide range of substrate tolerance under mild conditions and provides an alternative for the structural elaboration of quinazoline compounds.

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Methods Mentioned

BETA
column chromatography
silica
gel column chromatography
NMR

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