Rhodium-catalyzed cyclopropanation of fluorinated olefins: a straightforward route to highly functionalized fluorocyclopropanes

Organic Letters
Amandine PonsXavier Pannecoucke

Abstract

An efficient access to highly functionalized monofluorocyclopropanes is described. The developed methodology allowed straightforward access to a large panel of polysubstituted fluorinated cyclopropanes in good to excellent yields and good diastereoselectivities. The Rh-catalyzed cyclopropanation proved to be efficient on several fluorinated olefins and several diazo compounds. This method represents the first general route to complex fluorinated cyclopropanes.

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Citations

Apr 28, 2016·Organic Letters·Pauline RullièreAndré B Charette
Jul 2, 2016·The Journal of Organic Chemistry·Kuiyong DongXinfang Xu
Mar 2, 2017·Organic & Biomolecular Chemistry·Kankanala Ramakrishna, Chinnappan Sivasankar
Dec 1, 2015·Chemical Communications : Chem Comm·Maciej GiedykDorota Gryko
May 29, 2018·Chemistry : a European Journal·Wei-Sheng HuangPhilippe Jubault
Mar 8, 2016·Chemistry : a European Journal·Amandine PonsPhilippe Jubault

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