Rhodium(III)-Catalyzed Redox-Neutral 1,1-Cyclization of N-Methoxy Benzamides with Maleimides via C-H/N-H/N-O Activation: Detailed Mechanistic Investigation

The Journal of Organic Chemistry
Balu RameshMasilamani Jeganmohan

Abstract

An Rh(III)-catalyzed 1,1-cyclization of N-methoxy benzamides with maleimides providing isoindolinone spirosuccinimides through N-H/C-H/N-O bond activation is described. The detailed mechanistic investigation including isolation of key metalacycle intermediate, deuterium labeling studies, and DFT calculations were performed. The computational study reveals that the AcOH that formed in the reaction medium plays a key role in the N-OMe bond cleavage and the oxidation of Rh(I) to Rh(III).

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Citations

May 20, 2020·Chemistry : a European Journal·Herbert WaldmannCarsten Strohmann
Nov 27, 2020·Chemical Communications : Chem Comm·Sivakalai MayakrishnanNaryanan Uma Maheswari
Oct 31, 2020·Chemistry : a European Journal·Risto Savela, Carolina Méndez-Gálvez

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