Rhodococcus equi

Veterinary Research
Wim G Meijer, J F Prescott

Abstract

Rhodococcus equi is an important cause of subacute or chronic abscessating bronchopneumonia of foals up to 3-5 months of age. It shares the lipid-rich cell wall envelope characteristic of the mycolata, including Mycobacterium tuberculosis, as well as the ability of pathogenic members of this group to survive within macrophages. The possession of a large virulence plasmid in isolates recovered from pneumonic foals is crucial for virulence. The plasmid contains an 27 kb pathogenicity island (PI) that encodes seven related virulence-associated proteins (Vaps), including the immunodominant surface-expressed protein, VapA. Only PI genes are differentially expressed when the organism is grown in macrophages in vitro. Ten of the PI genes, including six Vap genes, have signal sequences, suggesting that they are exported from the cell to interact with the macrophage. Different PI genes are regulated by temperature, pH, iron, oxidative stress and probably also by magnesium, all environmental changes encountered after environmental R. equi are inhaled in dust and are ingested into macrophages in the lung. The basis of pathogenicity of R. equi is its ability to multiply in and eventually to destroy alveolar macrophages. Infectivity is larg...Continue Reading

Citations

Jul 17, 2012·Applied and Environmental Microbiology·Marianna A PatrauchanWilliam W Mohn
Nov 26, 2010·Applied and Environmental Microbiology·E J SummerR Young
May 15, 2007·Journal of Bacteriology·Gavin A ByrneWim G Meijer
Dec 25, 2007·Journal of Bacteriology·Raúl Miranda-CasoLuengoWim G Meijer
Mar 28, 2013·BMC Research Notes·Agueda Castagna de VargasShinji Takai
Oct 26, 2011·American Journal of Veterinary Research·Dominic R DawsonMaria Julia B Felippe
May 21, 2009·FEMS Microbiology Reviews·Kristine von Bargen, Albert Haas
May 23, 2015·Genome Announcements·Elham EhsaniRamiro Vilchez-Vargas
Apr 29, 2014·Frontiers in Physiology·Carla C C R de CarvalhoMiguel Viveiros
Sep 8, 2006·Journal of Veterinary Internal Medicine·Natalie D HalbertRonald J Martens
Oct 4, 2007·Equine Veterinary Journal·G MuscatelloJ A Vazquez-Boland
Apr 30, 2010·Memórias do Instituto Oswaldo Cruz·Paulo da SilvaClarice Queico Fujimura Leite
Jun 20, 2006·International Journal of Medical Microbiology : IJMM·Julien CauchardJean Jacques Ballet
Sep 19, 2006·Veterinary Microbiology·Yanlong PeiJohn F Prescott
Mar 6, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Katia VarelloElena Bozzetta
Jul 28, 2006·Antonie van Leeuwenhoek·Marco Polidori, Albert Haas
Aug 6, 2009·Reproduction in Domestic Animals = Zuchthygiene·C Ortega-FerrusolaF J Peña
Dec 17, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Monica VennerWerner Siegmund
Jan 1, 2008·Microbes and Environments·Wataru Kitagawa, Tomohiro Tamura
Nov 17, 2009·Journal of Immunotoxicology·Vito G Sasseville, Keith G Mansfield
Nov 20, 2012·Antonie van Leeuwenhoek·Amanda L JonesMichael Goodfellow
Apr 2, 2015·Journal of Equine Science·Irfan Ahmad MirGulzar Ahmad Badroo
Dec 15, 2015·The Journal of Veterinary Medical Science·Ilona StefańskaTomasz Dzieciątkowski
Dec 26, 2008·Clinical and Vaccine Immunology : CVI·M Julia B F FlaminioSteeve Giguère
Aug 4, 2007·The Journal of Infectious Diseases·Alain A Ocampo-SosaJose A Vazquez-Boland
Aug 2, 2014·Acta Crystallographica. Section D, Biological Crystallography·Jean L WhittinghamAnthony J Wilkinson
Dec 1, 2013·Equine Veterinary Journal. Supplement·J CrowleyG Muscatello

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