Abstract
Recoverin, a calcium-binding protein, is supposed to have rhodopsin kinase as a target in the retinal rod cell. In the present work, we show that efficiency of recoverin as an inhibitor of rhodopsin phosphorylation in bovine rod outer segments is inversely proportional to the level of rhodopsin bleaching. These results, together with the data obtained previously in a reconstituted system (Senin et al. (1997) Biochem. J. 321, 551-555), allow us to hypothesize that recoverin might be responsible for a Ca2(+)-dependent regulation of the kinase in vivo, preventing it from participating in the phosphorylation of unbleached rhodopsin.
References
Jun 21, 1977·Biochimica Et Biophysica Acta·S E Ostroy
Apr 19, 1979·Biochimica Et Biophysica Acta·P P SchnetkampF J Daemen
Sep 15, 1992·European Journal of Biochemistry·N G BrownM Akhtar
Feb 22, 1991·Science·A M DizhoorL Stryer
Jan 24, 1989·Biochemistry·K PalczewskiT S Ingebritsen
Aug 12, 1986·Biochemistry·H E Hamm, M D Bownds
Aug 15, 1970·Nature·U K Laemmli
Apr 10, 1984·Biochemistry·B R AtonM L Jackson
Jun 8, 1982·Biochemistry·U Wilden, H Kühn
Jul 7, 1995·The Journal of Biological Chemistry·V A KlenchinM D Bownds
Jul 28, 1995·The Journal of Biological Chemistry·C K ChenJ B Hurley
Dec 6, 1993·FEBS Letters·E N Gorodovikova, P P Philippov
Aug 1, 1994·FEBS Letters·E N GorodovikovaP P Philippov
Apr 15, 1993·European Journal of Biochemistry·K R Dean, M Akhtar
Nov 27, 1995·FEBS Letters·I I SeninP P Philippov
Mar 1, 1996·The Journal of Biological Chemistry·H OhguroK Palczewski
May 14, 1996·Biochemistry·K R Dean, M Akhtar
Aug 16, 1996·The Journal of Biological Chemistry·B M BinderV Y Arshavsky
Jan 15, 1997·The Biochemical Journal·I I SeninP P Philippov
Sep 26, 1988·FEBS Letters·Charles FowlesM Akhtar
Citations
Mar 31, 2000·Journal of Neuroscience Research·W CaoJ F McGinnis
Jul 9, 1998·Neuroscience Letters·N Dalil-ThineyC Versaux-Botteri
May 14, 2003·Progress in Retinal and Eye Research·Tadao MaedaKrzysztof Palczewski
Dec 15, 2000·The Biochemical Journal·R D Burgoyne, J L Weiss
Aug 25, 2001·Annual Review of Neuroscience·M E Burns, D A Baylor
Jan 31, 2006·Cancer Immunology, Immunotherapy : CII·Alexandr V BazhinStefan B Eichmüller
Aug 1, 2012·Cellular Signalling·Mikhail A KutuzovNelly Bennett
Dec 8, 2000·Biochimica Et Biophysica Acta·M SalleseA De Blasi
Jan 5, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L IacovelliA de Blasi
Jul 17, 1998·Vision Research·J B HurleyG A Niemi