Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline

Development
Marco GallioC Samakovlis

Abstract

EGF-receptor ligands act as chemoattractants for migrating epithelial cells during organogenesis and wound healing. We present evidence that Rhomboid 3/EGF signalling, which originates from the midline of the Drosophila ventral nerve cord, repels tracheal ganglionic branches and prevents them from crossing it. rho3 acts independently from the main midline repellent Slit, and originates from a different sub-population of midline cells: the VUM neurons. Expression of dominant-negative Egfr or Ras induces midline crosses, whereas activation of the Egfr or Ras in the leading cell of the ganglionic branch can induce premature turns away from the midline. This suggests that the level of Egfr intracellular signalling, rather than the asymmetric activation of the receptor on the cell surface, is an important determinant in ganglionic branch repulsion. We propose that Egfr activation provides a necessary switch for the interpretation of a yet unknown repellent function of the midline.

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Citations

Oct 7, 2004·Science's STKE : Signal Transduction Knowledge Environment·Alan Wells, Laura Lillien
Nov 16, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rika Maruyama, Deborah J Andrew
Feb 26, 2008·Biochemical and Biophysical Research Communications·Fergal O'Farrell, Per Kylsten
Mar 7, 2006·Developmental Biology·Allison MacMullin, J Roger Jacobs
Sep 26, 2009·Developmental Biology·Deborah J Andrew, Andrew J Ewald
Jul 18, 2016·Seminars in Cell & Developmental Biology·Ben-Zion Shilo
Aug 9, 2016·Seminars in Cell & Developmental Biology·Viorica L LastunMatthew Freeman
Dec 12, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Fergal O'FarrellPer Kylsten

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