PMID: 2110920Feb 1, 1990Paper

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster

Genes & Development
E BierY N Jan

Abstract

rhomboid (rho) belongs to a group of four genes involved in the elaboration of positional information at a ventrolateral level in the Drosophila embryo. Mutations at any of these four loci also lead to a variety of other phenotypes, including reduction in the number of stretch receptor organs (chordotonal organs) in the peripheral nervous system (PNS). We have cloned rho with the aid of a lacZ-bearing P-element inserted into the rho gene. In the early blastoderm stage, a putative rho transcript is expressed in ventrolateral strips corresponding to the domain of activity of the rho gene on the embryonic fate map. Later expression of the transcript correlates with regions of the embryo that are disrupted in rho mutants and includes a cell that may be the precursor for the missing stretch receptor organs. We hypothesize that rho acts very early in differentiation pathways to specify the identities of domains and isolated precursor cells. Sequence analysis suggests that this transcript codes for a trans-membrane protein.

References

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C J O'Kane, W J Gehring
Jan 30, 1986·Biochimica Et Biophysica Acta·J K Mohana Rao, P Argos
May 26, 1987·Nucleic Acids Research·R KlemenzW J Gehring
May 28, 1985·Biochimica Et Biophysica Acta·P KleinC DeLisi
Oct 15, 1984·Journal of Molecular Biology·D EisenbergR Wall
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P R Langer-SaferD C Ward
Jan 22, 1982·Nucleic Acids Research·S M Mount
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·G JürgensH Kluding
Mar 1, 1983·Wilhelm Roux's Archives of Developmental Biology·Ruth LehmannJosé A Campos-Ortega

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Citations

Jan 1, 1996·Developmental Genetics·C KlämbtA Stollewerk
Jan 1, 1996·Developmental Genetics·R Brewster, R Bodmer
Nov 26, 1999·Developmental Genetics·B R Lanoue, J R Jacobs
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E Bier
Jan 1, 1991·Developmental Genetics·N PerrimonA Brand
Jul 1, 1993·Trends in Neurosciences·H Keshishian, A Chiba
Mar 1, 1994·Trends in Genetics : TIG·H Ruohola-BakerY N Jan
Mar 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·J R NambuS T Crews
Dec 2, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·M Wilcox
Jun 1, 1991·Mechanisms of Development·A N BillinS J Poole
Feb 1, 1992·Mechanisms of Development·M WhiteleyJ A Kassis
Apr 1, 1994·Mechanisms of Development·M J Sonnenfeld, J R Jacobs
Oct 5, 2001·Trends in Genetics : TIG·V Hatini, S DiNardo
May 1, 1997·Trends in Genetics : TIG·R Schweitzer, B Z Shilo
Feb 1, 1997·Mechanisms of Development·H ScholzC Klämbt
Aug 30, 2002·Current Opinion in Genetics & Development·Sinisa Urban, Matthew Freeman
Sep 8, 1998·Current Opinion in Genetics & Development·M Freeman
Sep 8, 1998·Current Opinion in Genetics & Development·B L Hogan, J M Yingling
Jun 6, 2000·Current Biology : CB·C Klämbt
Feb 1, 2003·Trends in Cell Biology·Andreas Weihofen, Bruno Martoglio
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y N Jan, L Y Jan
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L Boulianne, W S Trimble
Jan 17, 2003·Molecular Biology of the Cell·José A BotellaStephan Schneuwly
May 2, 2001·The EMBO Journal·Y NibuM Levine
Dec 18, 2002·The EMBO Journal·Matthew Freeman
Mar 15, 2012·Journal of Experimental Botany·Elinor P ThompsonBeverley J Glover
Oct 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huafei ZouLu-Yuan Li
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Gregory T Reeves, Angelike Stathopoulos
Aug 1, 1997·Genes & Development·A M HuangM Levine

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