Abstract
Rhubarb Peony Decoction (RPD) is a formula of traditional Chinese medicine chronicled in Jin Gui Yao Lve, commonly used to treat ulcerative colitis (UC). However, the underlying mechanism of RPD treating UC remains elusive. In our study, we investigated the therapeutic efficacy of RPD and potential mechanism involved in inhibiting dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. The colitis was induced by DSS in mice for 5 days and estimated body weight loss, disease activity index (DAI) and colon length. Histological changes were observed by H&E staining. The number and abundance of gut mircrobiota were measured with 16 S rDNA sequencing. GC-MS was used to detect the concentration of short chain fatty acids (SCFAs) in cecum. Flow cytometry analyzed the proportion of Th17 and Treg cells in mesenteric lymph nodes (MLNs). IL-17A and Foxp3 in colon were determined by immunohistochemical analyses. The level of cytokine was determined by Multi-Analyte Flow Assay Kit. Administration of RPD significantly alleviated the pathological changes of UC mice, involving rescued the inflammation-related reduction of colon length, ameliorated body weight loss and damaged tissue. In addition, RPD altered the gut microbiota, involv...Continue Reading
Citations
Mar 19, 2020·Food & Function·Linlin FanShaoping Nie
May 30, 2019·BioMed Research International·Wenyan GaoYang Gong
May 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuxuan DingZhanqi Tong
Aug 31, 2020·Chinese Medicine·Hong XiangDeshi Dong
Dec 19, 2019·Frontiers in Pharmacology·Ziwen YuanYanming Wei
Nov 9, 2019·Microbiome·Baokun HeJ Marc Rhoads
Jan 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wenfeng XuPengfei Jin
May 21, 2020·Frontiers in Pharmacology·Yingmei DongJianjian Ji
Jun 25, 2020·Trials·Omid SadeghiAhmad Esmaillzadeh
Dec 21, 2019·The Journal of Pharmacy and Pharmacology·Yongjing XiangYongxiang Gao
Sep 3, 2020·World Journal of Gastroenterology : WJG·Bei YueWei Dou
Feb 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yong-Li HuaYan-Ming Wei
Feb 19, 2021·Frontiers in Pharmacology·Zhiwei MiaoBai Ye
Mar 18, 2021·Food & Function·Yi WangXu Wu
Feb 25, 2021·The American Journal of Chinese Medicine·Xiao LiHaixue Kuang
Oct 17, 2020·Journal of Translational Internal Medicine·Asli SemizAlaattin Sen
Apr 30, 2021·International Immunopharmacology·Yongzhi HuaLi Cui
May 1, 2021·Experimental Biology and Medicine·Leichang ZhangWu Liao
Jun 1, 2021·Frontiers in Pharmacology·Zhuang-Peng ChangJun-Jin Liu
Jun 5, 2021·Veterinary Parasitology·Bian-Hua ZhouHong-Wei Wang
Jun 20, 2021·Drug Development Research·Huanhuan ZhuMinying Wang
Jul 9, 2021·Frontiers in Pharmacology·Bing'e MaChaoqun Ma
Aug 12, 2021·Phytotherapy Research : PTR·Bo XuLian Zhou
Sep 14, 2021·Frontiers in Microbiology·Mei YangJiashun Chen
Nov 23, 2021·Frontiers in Pharmacology·Yifan WangXudong Tang
Mar 26, 2020·Current Drug Targets·Tingting ZhaoYouhua Xu