Rhus coriaria L. (Sumac) Evokes Endothelium-Dependent Vasorelaxation of Rat Aorta: Involvement of the cAMP and cGMP Pathways

Frontiers in Pharmacology
Mohammad A AnwarAli H Eid

Abstract

Rhus coriaria L. (sumac) is widely used in traditional remedies and cuisine of countries of the Mediterranean as well as Central and South-West Asia. Administration of sumac to experimental models and patients with diverse pathological conditions generates multi-faceted propitious effects, including the quality as a vasodilator. Together, the effects are concertedly channeled toward cardiovasobolic protection. However, there is paucity of data on the mechanism of action for sumac's vasodilatory effect, an attribute which is considered to be advantageous for unhealthy circulatory system. Accordingly, we sought to determine the mechanisms by which sumac elicits its vasorelaxatory effects. We deciphered the signaling networks by application of a range of pharmacological inhibitors, biochemical assays and including the quantification of cyclic nucleotide monophosphates. Herein, we provide evidence that an ethanolic extract of sumac fruit, dose-dependently, relaxes rat isolated aorta. The mechanistic effect is achieved via stimulation of multiple transducers namely PI3-K/Akt, eNOS, NO, guanylyl cyclase, cGMP, and PKG. Interestingly, the arachidonic acid pathway (cyclooxygenases), adenylyl cyclase/cAMP and ATP-dependent potassium cha...Continue Reading

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Citations

Jun 20, 2019·Biomolecules·Adnan BadranAli H Eid
Jun 20, 2020·Clinical Science·Manal Muin FardounAli H Eid
Sep 10, 2020·International Journal of Molecular Sciences·Nadine WehbeElias Baydoun
Mar 3, 2020·Current Hypertension Reports·Zena WehbeAli H Eid
Jul 18, 2020·International Journal of Molecular Sciences·Humna BhaganiAli H Eid
Jul 28, 2020·International Journal of Molecular Sciences·Nadine WehbeAli H Eid
Jan 13, 2021·Antioxidants·Halima AlsamriRabah Iratni
Oct 21, 2019·Vascular Pharmacology·Manal FardounAli H Eid
Nov 26, 2020·International Journal of Molecular Sciences·Adnan BadranAli H Eid

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