Rhythmic firing of medial septum non-cholinergic neurons

Neuroscience
M SerafinM Mühlethaler

Abstract

The presence of theta rhythm (5-10 Hz) in the hippocampus has been shown to enable long-term potentiation, a synaptic mechanism which has been proposed to underlie learning and memory. Medial septum cholinergic and GABAergic neurons that project to the hippocampus have been hypothesized to play conjointly a major role in the genesis of this rhythm. Building upon previous studies that have established the electrophysiological criteria for distinguishing cholinergic and non-cholinergic neurons in this area, it is demonstrated here that medial septum non-cholinergic neurons, putatively GABAergic, have the ability to discharge in rhythmic clusters of action potentials occurring at frequencies ranging from 1 to 8 Hz. Within the clusters, the firing frequency of action potentials varied between 13 and 57 Hz in a voltage-dependent manner. In addition, small voltage-dependent subthreshold membrane potential oscillations (16-54 Hz) were observed between clusters. Both subthreshold oscillations and clusters were eliminated by tetrodotoxin at 1 microM. These results indicate that non-cholinergic medial septum neurons could convey to the hippocampus not only theta but also higher frequency rhythmicity in the beta-gamma range (20-60 Hz).

References

Apr 1, 1992·Hippocampus·L S Leung
May 1, 1990·Trends in Neurosciences·M Stewart, S E Fox
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M SteriadeG Oakson
Dec 1, 1984·Brain Research Bulletin·N J WoolfL L Butcher
Aug 1, 1995·Current Opinion in Neurobiology·G Buzsáki, J J Chrobak
Mar 10, 1995·Science·J E Lisman, M A Idiart
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·M JoliotR Llinás
Aug 1, 1993·Progress in Neurobiology·B H Bland, L V Colom
Mar 22, 1993·The Journal of Comparative Neurology·I GrittiB E Jones

❮ Previous
Next ❯

Citations

Aug 10, 2006·Journal of Computational Neuroscience·Balázs Ujfalussy, Tamás Kiss
Sep 23, 2000·Behavioural Brain Research·W H GriffithD Murchison
Mar 1, 2000·Journal of Biological Physics·R A Chizhenkova, V Y Chernukhin
Oct 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hao ZhangMiguel A L Nicolelis
May 28, 2005·The Journal of Physiology·F ManseauS Williams
Oct 4, 2005·The European Journal of Neuroscience·Magdalena Sanhueza, Juan Bacigalupo
Feb 8, 2002·Neuron·György Buzsáki
Sep 30, 2016·Journal of Physiology, Paris·Holger DannenbergMichael E Hasselmo
Feb 15, 2018·Journal of Neurophysiology·James R HinmanMichael E Hasselmo
Aug 10, 2017·Journal of Neurochemistry·Gretchen Y López-HernándezLorna W Role
Apr 1, 2021·Cognitive Neurodynamics·Ben CaoYuye Li
Jun 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Golan KarvatIlka Diester

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.