Rhythmic melatonin response of the Syrian hamster pineal gland to norepinephrine in vitro and in vivo

Journal of Pineal Research
G M VaughanA D Mason

Abstract

Norepinephrine (NE, 10(-6) M) stimulated melatonin accumulation in the incubation medium of rat (but not Syrian hamster) pineals taken at the end of the light phase. However, NE elevated melatonin accumulation in the medium of pineals taken after 20 min of light exposure of animals of either species at 6 h into the 10-h dark phase. A dose response to 10(-7)-10(-5) M NE was observed in both the medium and pineals upon incubation of pineals taken from rats at 4 h into the light phase and from hamsters after 20 min light exposure at 6 h into the dark phase. Approximately 95% of the melatonin present was in the medium. The incubation time was 4 h in all cases. Subcutaneous injection of 1 microgram/g NE (either at the end of the light phase or after 30 min of light at 6 h into the dark phase) did not stimulate in vivo Syrian hamster pineal melatonin content determined 1 or 2 h after injection, whether the hamsters were placed in light or darkness after the injection. However, after 30 min of light beginning at 6 h into dark, injection of 5 micrograms/g desipramine (DMI, a blocker of catecholamine uptake into nerve endings) allowed a dramatic hamster pineal melatonin response to additional injection of 1 microgram/g NE, observed at 1...Continue Reading

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Citations

Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·G M VaughanA D Mason
Oct 1, 1991·Journal of Neuroendocrinology·Z RékésiB Mess
Jun 25, 2009·Journal of Neuroendocrinology·A SalingreV Simonneaux
Jan 1, 1989·Journal of Pineal Research·V SimonneauxH Vaudry
Jan 1, 1988·Journal of Neurochemistry·P J MorganG Riddoch
May 12, 2006·Chronobiology International·Valérie SimonneauxPaul Pévet

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