Rhythmogenesis evolves as a consequence of long-term plasticity of inhibitory synapses

Scientific Reports
Sarit Soloduchin, Maoz Shamir

Abstract

Brain rhythms are widely believed to reflect numerous cognitive processes. Changes in rhythmicity have been associated with pathological states. However, the mechanism underlying these rhythms remains unknown. Here, we present a theoretical analysis of the evolvement of rhythm generating capabilities in neuronal circuits. We tested the hypothesis that brain rhythms can be acquired via an intrinsic unsupervised learning process of activity dependent plasticity. Specifically, we focused on spike timing dependent plasticity (STDP) of inhibitory synapses. We detail how rhythmicity can develop via STDP under certain conditions that serve as a natural prediction of the hypothesis. We show how global features of the STDP rule govern and stabilize the resultant rhythmic activity. Finally, we demonstrate how rhythmicity is retained even in the face of synaptic variability. This study suggests a role for inhibitory plasticity that is beyond homeostatic processes.

References

Jan 1, 1984·Biological cybernetics·K Matsuoka
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·W O Friesen
Dec 29, 2000·Nature Neuroscience·L F Abbott, S B Nelson
Feb 15, 2001·Physical Review Letters·J RubinH Sompolinsky
Apr 3, 2001·Annual Review of Neuroscience·G Bi, M Poo
Mar 23, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jan Karbowski, G Bard Ermentrout
Jun 13, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Dezhe Z Jin, H Sebastian Seung
Sep 27, 2003·Neural Computation·Oren ShrikiHaim Sompolinsky
Feb 19, 2005·Science·Christian K MachensCarlos D Brody
Jul 15, 2005·Journal of Neurophysiology·Romain Brette, Wulfram Gerstner
Oct 1, 2005·Biological cybernetics·Oliver G WenischJ Leo van Hemmen
Jul 4, 2006·Physiological Reviews·Yang Dan, Mu-Ming Poo
Aug 25, 2006·Journal of Neurophysiology·Julie S HaasH D I Abarbanel
Sep 27, 2006·Neural Computation·Maoz Shamir
Mar 21, 2007·Nature Neuroscience·Emre AksayDavid W Tank
Feb 16, 2008·Annual Review of Neuroscience·Natalia Caporale, Yang Dan
Feb 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eugene M Izhikevich, Gerald M Edelman
May 21, 2008·Biological cybernetics·Abigail MorrisonWulfram Gerstner
Jul 23, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hideyuki CâteauTomoki Fukai
Aug 8, 2009·Physical Review Letters·Marcelo O MagnascoGuillermo A Cecchi
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothée MasquelierSimon J Thorpe
Jan 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minoru HondaShinya Kuroda
Feb 1, 2012·PLoS Computational Biology·Yotam Luz, Maoz Shamir
Jun 28, 2012·Neural Computation·Matthieu GilsonJ Leo van Hemmen
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maxim BazhenovBrian H Smith
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Supriya GhoshSumantra Chattarji

❮ Previous
Next ❯

Citations

Mar 12, 2020·International Journal of Molecular Sciences·Daniela GandolfiJonathan Mapelli
Sep 26, 2019·Frontiers in Behavioral Neuroscience·Antonio Benítez-Burraco, Elliot Murphy
Aug 14, 2019·Current Opinion in Neurobiology·Maoz Shamir

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Neurobiologiae Experimentalis
N A Buchwald, C D Hull
IEEE Transactions on Biomedical Circuits and Systems
Jose M Cruz-AlbrechtNarayan Srinivasa
© 2022 Meta ULC. All rights reserved