PMID: 8946258Dec 1, 1996Paper

Rhythms of glutamic acid decarboxylase mRNA in the suprachiasmatic nucleus

Journal of Biological Rhythms
K L HuhmanH E Albers

Abstract

The purpose of the present study was to determine whether there is a rhythm in glutamic acid decarboxylase (GAD) message in the suprachiasmatic nucleus (SCN) of rats housed in a light:dark cycle. The mRNAs encoding two isoforms of GAD (i.e., GAD65 and GAD67) were examined using in situ hybridization histochemistry. Computerized image analysis of film autoradiographs revealed that GAD65 mRNA was significantly higher in the light than it was in the dark. GAD67 mRNA levels were lower overall and did not decrease significantly in the dark. Following emulsion autoradiography, silver grain counts over individual SCN cells indicated that GAD65 mRNA was highest in the dorsomedial hypothalamus during the light. These data suggest that GAD mRNA varies rhythmically in the SCN and that mRNA levels are regulated differently within SCN subdivisions during the light:dark cycle.

References

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Citations

Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Oct 16, 1999·Brain Research. Molecular Brain Research·M J Duncan, D L Wheeler
Feb 27, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Christopher Ehlen, Ketema N Paul
Feb 17, 2006·Journal of Circadian Rhythms·Vallath Reghunandanan, Rajalaxmy Reghunandanan
Dec 5, 2013·Behavioural Brain Research·Jorge R Bergado-AcostaOliver Stork
Sep 24, 2015·The European Journal of Neuroscience·Michael MoldavanCharles N Allen
Sep 13, 2005·Annals of the New York Academy of Sciences·Karla KretschmannovaHana Zemkova
Dec 13, 2006·The European Journal of Neuroscience·Colleen M NovakH Elliott Albers
May 8, 2016·The Journal of Endocrinology·Jennifer A Evans
Feb 12, 2002·Journal of Biological Rhythms·Gabriella B LundkvistRussell H Hill
Nov 8, 2018·The European Journal of Neuroscience·Vania Carmona-AlcocerJennifer A Evans
Dec 7, 2018·The European Journal of Neuroscience·Lydia HannouValérie Mongrain
Mar 22, 2020·Journal of Neurochemistry·Daisuke OnoSato Honma
Mar 22, 2018·The Journal of Physiological Sciences : JPS·Daisuke OnoSato Honma
Dec 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M Novak, H E Albers
Apr 4, 2017·Neural Plasticity·Malgorzata Jasinska, Elzbieta Pyza
Feb 5, 2021·Journal of Neurochemistry·Rodolfo Costa, Sara Montagnese
Nov 30, 2016·Frontiers in Neuroendocrinology·H Elliott AlbersDaniel L Hummer
Jul 15, 2021·Journal of Neurophysiology·Michael MoldavanCharles N Allen

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