Rhythms of metabolism in adipose tissue and mitochondria

Neurobiology of Sleep and Circadian Rhythms
Yasemin Onder, Carla B Green

Abstract

Circadian clocks synchronize the daily functions of organisms with environmental cues like light-dark cycles and feeding rhythms. The master clock in the suprachiasmatic nucleus in the hypothalamus of the brain and the many clocks in the periphery are organized in a hierarchical manner; the master clock synchronizes the peripheral clocks, and the peripheral clocks provide feedback to the master clock in return. Not surprisingly, it has been shown that circadian rhythms and metabolism are closely linked. Metabolic disorders like obesity have a large cost to the individual and society and they are marked by adipose tissue and mitochondrial dysfunction. Mitochondria are central to energy metabolism and have key functions in processes like ATP production, oxidative phosphorylation, reactive oxygen species production and Ca2+ homeostasis. Mitochondria also play an important role in adipose tissue homeostasis and remodeling. Despite the extensive research investigating the link between circadian clock and metabolism, the circadian regulation of adipose tissue and mitochondria has mostly been unexplored until recently, and the emerging data in this topic are the focus of this review.

Citations

Oct 11, 2019·International Journal of Molecular Sciences·Mohammad Hosein FarzaeiAnupam Bishayee
Jan 16, 2021·International Journal of Molecular Sciences·Andy W C ManNing Xia
Aug 4, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mami MatsushitaMasayuki Saito

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Methods Mentioned

BETA
acetylation

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