Ribavirin and inosiplex: a review of their present status in viral diseases

Drugs
T W Chang, R C Heel

Abstract

A considerable amount of information has accumulated during the past 10 years in the search for antiviral agents. Ribavirin and inosiplex are 2 interesting developments to come out of this search. Ribavirin, a synthetic nucleoside, has an unusually wide spectrum of antiviral activity, especially when tested in vitro. A large number of RNA and DNA viruses are sensitive, especially herpes viruses, poxvirus, influenza, parainfluenza, reovirus, togavirus, and RNA tumour viruses. The in vivo antiviral spectrum of activity is much narrower, with activity against herpes virus, influenza, parainfluenza, measles and adenoviruses. However, controlled clinical trials have not been uniformly successful in treating influenza, hepatitis, herpes simplex and herpes zoster. Inosiplex has been shown to have antiviral activity in vivo against influenza, herpes simplex, rhinovirus and vaccinia virus infections. However, antiviral activity has not been consistently demonstrated, and this observation led to further studies which revealed its immunomodulating effects. The accumulated evidence has indicated that inosiplex is more a prohost agent rather than an antiviral drug. Immune functions which are depressed during viral infection can be restored ...Continue Reading

Citations

Jul 31, 2010·Nucleic Acids Research·Christina PriestMasha V Poyurovsky
Nov 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F NaccariA De Sarro
Jun 16, 2007·Biochimie·Claude SouvignetChristian Trepo
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