Abstract
A considerable amount of information has accumulated during the past 10 years in the search for antiviral agents. Ribavirin and inosiplex are 2 interesting developments to come out of this search. Ribavirin, a synthetic nucleoside, has an unusually wide spectrum of antiviral activity, especially when tested in vitro. A large number of RNA and DNA viruses are sensitive, especially herpes viruses, poxvirus, influenza, parainfluenza, reovirus, togavirus, and RNA tumour viruses. The in vivo antiviral spectrum of activity is much narrower, with activity against herpes virus, influenza, parainfluenza, measles and adenoviruses. However, controlled clinical trials have not been uniformly successful in treating influenza, hepatitis, herpes simplex and herpes zoster. Inosiplex has been shown to have antiviral activity in vivo against influenza, herpes simplex, rhinovirus and vaccinia virus infections. However, antiviral activity has not been consistently demonstrated, and this observation led to further studies which revealed its immunomodulating effects. The accumulated evidence has indicated that inosiplex is more a prohost agent rather than an antiviral drug. Immune functions which are depressed during viral infection can be restored ...Continue Reading
Citations
Mar 1, 1984·Infection·J Drews
Jan 1, 1985·Infection·J Drews
Mar 11, 1990·Nucleic Acids Research·M I DawsonP D Hobbs
Jul 31, 2010·Nucleic Acids Research·Christina PriestMasha V Poyurovsky
Jul 1, 1986·Antimicrobial Agents and Chemotherapy·A MuñozA Pérez-Aranda
Dec 1, 1988·Antimicrobial Agents and Chemotherapy·R F SchinaziD Martino-Saltzman
Oct 1, 1994·Antimicrobial Agents and Chemotherapy·D M RyanC R Penn
Dec 17, 2005·BMC Pediatrics·Craig CampbellRenee Brannan
Nov 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F NaccariA De Sarro
Jun 16, 2007·Biochimie·Claude SouvignetChristian Trepo
Nov 1, 1988·International Journal of Dermatology·F P FlowersL A Turner
May 1, 1987·Infection Control : IC·M Eggleston
Feb 1, 1984·Drug Intelligence & Clinical Pharmacy·C S Conner
May 1, 1984·Drug Intelligence & Clinical Pharmacy·W J TaylorP R Dyken
Apr 1, 1984·Medical Hypotheses·R W Trewyn