Ribbon Synapses and Visual Processing in the Retina

Annual Review of Vision Science
Leon Lagnado, Frank Schmitz

Abstract

The first synapses transmitting visual information contain an unusual organelle, the ribbon, which is involved in the transport and priming of vesicles to be released at the active zone. The ribbon is one of many design features that allow efficient refilling of the active zone, which in turn enables graded changes in membrane potential to be transmitted using a continuous mode of neurotransmitter release. The ribbon also plays a key role in supplying vesicles for rapid and transient bursts of release that signal fast changes, such as the onset of light. We increasingly understand how the physiological properties of ribbon synapses determine basic transformations of the visual signal and, in particular, how the process of refilling the active zone regulates the gain and adaptive properties of the retinal circuit. The molecular basis of ribbon function is, however, far from clear.

References

Dec 10, 1971·Brain Research·E G Gray, H L Pease
Oct 6, 1994·Nature·R HeidelbergerG Matthews
Dec 18, 1998·Neuron·H von GersdorffM Tachibana
Feb 23, 1999·Neuron·L E Dobrunz, C F Stevens
Nov 9, 2000·Journal of Neurophysiology·Z H Pan, H J Hu
Feb 22, 2001·Neuron·H von Gersdorff
Jun 8, 2001·Neuron·F KawaiE Miyachi
Sep 6, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Lenzi, H von Gersdorff
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·G NevesL Lagnado
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yun WangThomas C Südhof
Dec 7, 2002·Neuron·Stephen A Baccus, Markus Meister
Feb 11, 2003·Neuron·T D Parsons, P Sterling
Feb 6, 2004·Current Biology : CB·Matthew HoltLeon Lagnado
Mar 9, 2004·Neuron·Ruth ReaRichard H Kramer

❮ Previous
Next ❯

Citations

Aug 8, 2018·Human Molecular Genetics·Juthaporn AssawachananontAnand Swaroop
May 17, 2019·Nature Communications·Haruhisa OkawaRachel O L Wong
Apr 19, 2020·The Journal of Physiology·Tamara RadulovicSamuel M Young
Jul 3, 2020·Journal of Neural Engineering·Paul WerginzDaniel Palanker
Aug 3, 2019·Physiological Reviews·Tobias MoserFrank Schmitz
Sep 25, 2017·Brain Structure & Function·Espen HartveitMargaret Lin Veruki
May 22, 2019·Nature Neuroscience·Ben JamesLeon Lagnado
Oct 15, 2019·ELife·Hiu-Tung C WongKatie Kindt
Apr 4, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Miriam RylJohann Helmut Brandstätter
Apr 28, 2021·Physiology·Robert Kavet, Joseph Brain
May 8, 2021·Frontiers in Neuroscience·Meimanat FathiZohreh Hosseinzadeh
May 8, 2021·Frontiers in Molecular Neuroscience·Luis Colón-CruzMartine Behra

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

sypHy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.