Ribes nigrum L. Prevents UVB-mediated Photoaging in Human Dermal Fibroblasts: Potential Antioxidant and Antiinflammatory Activity

Photochemistry and Photobiology
Lu LiTae-Hoo Yi

Abstract

Black currants (Ribes nigrum L, RN) are known as a "super fruit" to possess for their many potential health benefits such as the alleviation of oxidative stress-related disorders. However, little skin photoaging-related research has been done on the use of this agent. In the present study, we investigated the protective effects of RN in UVB-irradiated human dermal fibroblasts (NHDFs). RN treatment in UVB-irradiated skin models alleviated UVB-mediated photoaging through several mechanisms: Treatment with RN downregulated MAPK-related signaling models, such as those of activation protein 1 (AP-1) and nuclear factor kappa B (NF-κB). In addition, phase II gene heme oxygenase-1 (HO-1) was modulated by the increase in nuclear factor erythroid 2-related factor 2 (Nrf2) in the nuclear, and finally, transforming growth factor TGF-β was upregulated in vitro. Further study indicated that UVB-induced production of MMP-1 and IL-6 could be inhibited by PD 98059 (an inhibitor of ERK) and SP600125 (an inhibitor of JNK). Thus, RN improved the expression of type I procollagen and inhibited UVB-induced MMP-1 and IL-6 secretion through inactivating MAPK cascades. Therefore, RN is a suitable target for further investigation as an antiphotoaging age...Continue Reading

References

Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·M WlaschekK Scharffetter-Kochanek
Jan 24, 2002·Journal of Agricultural and Food Chemistry·Richard A MoyerRonald E Wrolstad
Feb 14, 2002·The Journal of Investigative Dermatology·Franck Verrecchia, Alain Mauviel
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
Sep 5, 2002·Ageing Research Reviews·Laure Rittié, Gary J Fisher
Oct 17, 2003·Phytochemistry·Jin-Ming KongR Brouillard
Jun 16, 2005·The Journal of Investigative Dermatology·Arianna L KimDavid R Bickers
May 25, 2006·Journal of Agricultural and Food Chemistry·Petros G KapasakalidisMichael H Gordon
May 1, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K A LyallL M Stevenson
Sep 17, 2009·Archives of Dermatological Research·Visalini Muthusamy, Terrence J Piva
Sep 10, 2013·Nutrition·Shivraj Hariram Nile, Se Won Park
Aug 19, 2014·Phytotherapy Research : PTR·Eunson HwangTae Hoo Yi
Sep 18, 2014·Journal of Natural Medicines·Zheng-Wang SunTae Hoo Yi

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Citations

Aug 11, 2020·Critical Reviews in Food Science and Nutrition·David Fonseca HernandezLuis Mojica
Aug 3, 2021·International Journal of Radiation Biology·Alena RyšaváAlena Rajnochová Svobodová

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