Abstract
Black currants (Ribes nigrum L, RN) are known as a "super fruit" to possess for their many potential health benefits such as the alleviation of oxidative stress-related disorders. However, little skin photoaging-related research has been done on the use of this agent. In the present study, we investigated the protective effects of RN in UVB-irradiated human dermal fibroblasts (NHDFs). RN treatment in UVB-irradiated skin models alleviated UVB-mediated photoaging through several mechanisms: Treatment with RN downregulated MAPK-related signaling models, such as those of activation protein 1 (AP-1) and nuclear factor kappa B (NF-κB). In addition, phase II gene heme oxygenase-1 (HO-1) was modulated by the increase in nuclear factor erythroid 2-related factor 2 (Nrf2) in the nuclear, and finally, transforming growth factor TGF-β was upregulated in vitro. Further study indicated that UVB-induced production of MMP-1 and IL-6 could be inhibited by PD 98059 (an inhibitor of ERK) and SP600125 (an inhibitor of JNK). Thus, RN improved the expression of type I procollagen and inhibited UVB-induced MMP-1 and IL-6 secretion through inactivating MAPK cascades. Therefore, RN is a suitable target for further investigation as an antiphotoaging age...Continue Reading
References
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·M WlaschekK Scharffetter-Kochanek
Jan 24, 2002·Journal of Agricultural and Food Chemistry·Richard A MoyerRonald E Wrolstad
Feb 14, 2002·The Journal of Investigative Dermatology·Franck Verrecchia, Alain Mauviel
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
Sep 5, 2002·Ageing Research Reviews·Laure Rittié, Gary J Fisher
Jan 25, 2003·Oncogene·Marcello ArsuraGail E Sonenshein
Oct 17, 2003·Phytochemistry·Jin-Ming KongR Brouillard
Feb 25, 2005·The British Journal of Dermatology·F RijkenP L B Bruijnzeel
Jun 16, 2005·The Journal of Investigative Dermatology·Arianna L KimDavid R Bickers
Feb 10, 2006·Rheumatology International·Zhiyong FanThomas Aigner
Apr 19, 2006·The Journal of Biological Chemistry·Min DingXianglin Shi
May 25, 2006·Journal of Agricultural and Food Chemistry·Petros G KapasakalidisMichael H Gordon
Mar 16, 2007·The Journal of Biological Chemistry·Rentian FengXiao-Ming Yin
Nov 6, 2007·Current Cancer Drug Targets·S J Cooper, G T Bowden
Oct 14, 2008·Genes & Nutrition·Young-Joon Surh, Hye-Kyung Na
May 1, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K A LyallL M Stevenson
Sep 17, 2009·Archives of Dermatological Research·Visalini Muthusamy, Terrence J Piva
Feb 10, 2010·Pharmaceutical Research·Som D Sharma, Santosh K Katiyar
Apr 19, 2011·Molecular Neurobiology·Giovanni ScapagniniGalvano Fabio
Sep 10, 2013·Nutrition·Shivraj Hariram Nile, Se Won Park
Aug 19, 2014·Phytotherapy Research : PTR·Eunson HwangTae Hoo Yi
Sep 18, 2014·Journal of Natural Medicines·Zheng-Wang SunTae Hoo Yi
Citations
Aug 11, 2020·Critical Reviews in Food Science and Nutrition·David Fonseca HernandezLuis Mojica
May 4, 2021·Journal of Ethnopharmacology·Qing SunHuakun Zhou
Aug 3, 2021·International Journal of Radiation Biology·Alena RyšaváAlena Rajnochová Svobodová