Riboflavin ameliorates cisplatin induced toxicities under photoillumination.

PloS One
I HassanImrana Naseem

Abstract

Cisplatin is an effective anticancer drug that elicits many side effects mainly due to induction of oxidative and nitrosative stresses during prolonged chemotherapy. The severity of these side effects consequently restricts its clinical use under long term treatment. Riboflavin is an essential vitamin used in various metabolic redox reactions in the form of flavin adenine dinucleotide and flavin mononucleotide. Besides, it has excellent photosensitizing property that can be used to ameliorate these toxicities in mice under photodynamic therapy. Riboflavin, cisplatin and their combinations were given to the separate groups of mice under photoilluminated condition under specific treatment regime. Their kidney and liver were excised for comet assay and histopathological studies. Furthermore, Fourier Transform Infrared Spectroscopy of riboflavin-cisplatin combination in vitro was also conducted to investigate any possible interaction between the two compounds. Their comet assay and histopathological examination revealed that riboflavin in combination with cisplatin was able to protect the tissues from cisplatin induced toxicities and damages. Moreover, Fourier Transform Infrared Spectroscopy analysis of the combination indicated a ...Continue Reading

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Citations

Sep 23, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Imrana NaseemSandesh Chibber
Dec 12, 2012·Cancer Biotherapy & Radiopharmaceuticals·Iftekhar HassanImrana Naseem
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Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Walaa AlharbiAli Alsalme

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Methods Mentioned

BETA
electrophoresis
light microscopy
Infrared Spectroscopy

Software Mentioned

Origin
GraphPad Prism

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