Riboflavin and UV light treatment of platelets: a protective effect of platelet additive solution?

Transfusion
P F van der MeerDirk de Korte

Abstract

Pathogen reduction technologies (PRTs) increase the safety of the blood supply, but are also associated with cell damage. Our aim was to investigate the effect of Mirasol PRT on platelet (PLT) concentrates stored in plasma and whether the use of a PLT additive solution (PAS) is able to improve in vitro quality. Twenty-two buffy coats (BCs) were pooled and split into two equal parts. To one half, 2 units of plasma were added, and to the other, 2 units of SSP+ PAS were added. Each part was equally split in half again (to resemble pooling five BCs) and PLT concentrates were prepared. One plasma PLT concentrate was Mirasol treated, and the other served as control; similarly, one SSP+ PLT concentrate was Mirasol treated, and the other not. PLT concentrates were stored for 8 days (n = 12). Mirasol PRT led to elevated lactate production in PLT concentrates in plasma, giving lower pH values throughout storage. The use of SSP+ mostly abrogated this effect, and Mirasol-treated PLT concentrates in SSP+ had only slightly higher lactate production rates and annexin A5 binding as control PLT concentrates in plasma. However, irrespective whether plasma or SSP+ was used, Mirasol PRT led to higher CD62P expression and lower hypotonic shock resp...Continue Reading

References

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Apr 14, 2004·Vox Sanguinis·T VandenBroekeUNKNOWN Biomedical Excellence for Safer Transfusion Working Party of the International Society of Blood Transfusion
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Nov 8, 2011·Blood Reviews·Valery Leytin
Feb 13, 2013·British Journal of Haematology·Armen V GyulkhandanyanValery Leytin

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Citations

May 3, 2016·Platelets·Peter A Smethurst
Aug 1, 2016·La Presse médicale·Miguel Lozano, Joan Cid
Feb 18, 2017·International Journal of Molecular Sciences·Giona SonegoNiels Lion
Sep 2, 2018·Hematology·Signe SperlingChristian Nielsen

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