PMID: 7284295Sep 1, 1981Paper

Riboflavin deficiency in man: effects on haemoglobin and reduced glutathione in erythrocytes of different ages

The British Journal of Nutrition
H J Powers, D I Thurnham

Abstract

1. Erythrocytes (RBC) from control and marginally riboflavin-deficient subjects were fractionated into nine fractions using a discrete density gradient. 2. Glutathione reductase (NAD(P)H: glutathione oxidoreductase; EC 1.6.4.2) activity and aspartate aminotransferase (EC 2.6.1.1) activity (with and without the appropriate co-enzymes) reduced glutathione, methaemoglobin, sulphaemoglobin and oxyhaemoglobin and susceptibility to peroxide were measured in RBC in the different fractions. 3. Glutathione reductase and aspartate aminotransferase activities and concentrations of reduced glutathione and oxyhaemoglobin all declined with age, while methaemogloblin, sulphaemoglobin and susceptibility to peroxide increased with age. 4. The only significant differences noted in the RBC from marginally-riboflavin-deficient subjects by comparison with controls, were lower glutathione reductase activities and higher concentrations of methaemoglobin. 5. The role of riboflavin in those systems controlling RBC integrity is discussed.

References

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Jan 1, 1977·Nutrition and Metabolism·H J Powers, D I Thurnham
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Apr 1, 1980·Biochemical Society Transactions·H J Powers, D I Thurnham
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Citations

Oct 14, 1985·Mechanisms of Ageing and Development·H ImanishiT Takino
Oct 1, 1994·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M Kurata, M Suzuki
Dec 7, 1985·Lancet·D I Thurnham
Aug 17, 2006·Antioxidants & Redox Signaling·Maurizio Minetti, Walter Malorni
Mar 22, 2014·The British Journal of Nutrition·Marziyeh Ashoori, Ahmad Saedisomeolia
Mar 21, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tunde MeyersGary L Myers
Apr 4, 2017·Scientific Reports·Zhonghao XinChangjiang Guo
Apr 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ovidiu MituIrina Iuliana Costache

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