PMID: 3518804Jun 3, 1986Paper

Riboflavin nutritional status and flavoprotein enzymes in streptozotocin-diabetic rats

Biochimica Et Biophysica Acta
A S Reddi

Abstract

Riboflavin nutritional status was assessed on the basis of activity coefficients of glutathione reductase in erythrocyte hemolysates of normal and streptozotocin-diabetic rats. Activity coefficient values higher than 1.3 were regarded as evidence of riboflavin deficiency. All diabetic animals were found to be riboflavin-deficient, with activity coefficient values of 1.47-2.11. Treatment of diabetic rats with either insulin or riboflavin returned their activity coefficients to normal. Rats fed a restricted diet had normal activity coefficient values. The erythrocyte glutathione reductase activity was significantly lower in diabetic rats, and the augmentation of enzyme activity in the presence of flavin-adenine dinucleotide (FAD) was 72% compared to 16% in normal rats. Hepatic activities of glutathione reductase and succinate dehydrogenase, both FAD-containing enzymes, were significantly lower in diabetic than in normal rats. Like activity coefficient values, all enzyme activities were normalized after insulin or riboflavin treatments. These data suggest that insulin and riboflavin enhance the synthesis of erythrocyte and hepatic FAD. The results of the present study suggest that experimental diabetes causes riboflavin deficiency...Continue Reading

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Citations

Nov 16, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Arja SiirtolaMatti K Salo
Nov 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M KurataN S Agar
Jul 3, 2009·Metabolism: Clinical and Experimental·Nadja ApeltManuel Pires Bicho
Jul 19, 2005·Biochemical and Biophysical Research Communications·Gábor NardaiPéter Csermely
Oct 1, 1987·Current Eye Research·J HorwitzD O Lightfoot
Sep 10, 1999·Experimental Animals·M SuzukiN S Agar
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Tirthankar SinhaMuayyad R Al-Ubaidi

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