Ribonucleases as novel chemotherapeutics : the ranpirnase example.

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
J Eugene Lee, Ronald T Raines

Abstract

Ranpirnase, a cytotoxic ribonuclease from the frog Rana pipiens, is the archetype of a novel class of cancer chemotherapeutic agents based on homologs and variants of bovine pancreatic ribonuclease (RNase A). Ranpirnase in combination with doxorubicin is in clinical trials for the treatment of unresectable malignant mesothelioma and other cancers. The putative mechanism for ranpirnase-mediated cytotoxicity involves binding to anionic components of the extracellular membrane, cytosolic internalization, and degradation of transfer RNA leading to apoptosis. The maintenance of ribonucleolytic activity in the presence of the cytosolic ribonuclease inhibitor protein is a key aspect of the cytotoxic activity of ranpirnase. The basis for its specific toxicity for cancer cells is not known. This review describes the development of ranpirnase as a cancer chemotherapeutic agent.

References

Jan 17, 1990·Journal of the National Cancer Institute·P DiasS Kumar
May 1, 1988·Cell and Tissue Kinetics·Z DarzynkiewiczK Shogen
Jul 21, 1995·The Journal of Biological Chemistry·Y WuR J Youle
Jun 1, 1997·Electrophoresis·G G SlivinskyD R Morrison
May 23, 1998·Journal of Molecular Biology·A V Kajava
Jul 29, 2000·Biochemistry·E NotomistaA Di Donato
May 19, 2001·Chemistry & Biology·P A Leland, R T Raines
Jul 20, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J Matousek
Sep 14, 2001·The Journal of Biological Chemistry·P A LelandR T Raines
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stanislaw M MikulskiKuslima Shogen
Feb 13, 2002·The Journal of Biological Chemistry·Shailendra K SaxenaRichard J Youle
Feb 19, 2002·Chemical Reviews·Ronald T. Raines
Jul 20, 2002·Experimental Cell Research·Jerzy GrabarekZbigniew Darzynkiewicz
Dec 17, 2002·Journal of Cell Science·Marcia C Haigis, Ronald T Raines
Feb 1, 2003·Nucleic Acids Research·Marcia C HaigisRonald T Raines
Apr 12, 2003·FEBS Letters·Alexander A Makarov, Olga N Ilinskaya
Apr 16, 2003·Cell Cycle·Barbara ArdeltZbigniew Darzynkiewicz
Oct 18, 2003·Advances in Experimental Medicine and Biology·Intae LeeKuslima Shogen
Dec 3, 2003·The Journal of Biological Chemistry·Vitaliy Y GorbatyukTai-huang Huang
Feb 27, 2004·Biochemical and Biophysical Research Communications·Byung-Moon KimYounghoon Lee
Mar 12, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Josef MatousekRonald T Raines
Nov 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·E A Merritt, M E Murphy
Feb 25, 2005·The Journal of Biological Chemistry·Antonello MerlinoFilomena Sica
Sep 17, 2005·Progress in Nucleic Acid Research and Molecular Biology·Kimberly A DicksonRonald T Raines
Sep 29, 2005·Journal of Molecular Biology·Thomas J RutkoskiRonald T Raines
Feb 25, 2006·The Journal of Biological Chemistry·Avvaru N Suhasini, Ravi Sirdeshmukh
Mar 22, 2006·Expert Opinion on Biological Therapy·Nick Pavlakis, Nicholas J Vogelzang
Feb 1, 1958·Proceedings of the National Academy of Sciences of the United States of America·D E Koshland
Apr 6, 2006·Handbook of Experimental Pharmacology·M Sioud
Apr 6, 2006·Handbook of Experimental Pharmacology·S Schubert, J Kurreck
Apr 14, 2006·Current Medicinal Chemistry·Alaeddin TafechChow H Lee
Apr 26, 2006·Expert Opinion on Emerging Drugs·Elizabeth Rose RayburnRuiwen Zhang

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Citations

Aug 14, 2010·Bioconjugate Chemistry·Thomas J RutkoskiRonald T Raines
Nov 11, 2010·Biochemistry·Tzu-Yuan ChaoRonald T Raines
Aug 11, 2011·Biochemistry·Tzu-Yuan Chao, Ronald T Raines
May 1, 2009·Biochemistry·Kimberly A Dickson, Ronald T Raines
Oct 19, 2011·ACS Chemical Biology·Alethia A HostetterVictoria J DeRose
Jan 24, 2013·Molecular BioSystems·Tzu-Yuan Chao, Ronald T Raines
Nov 26, 2008·AIDS Research and Human Retroviruses·Rebecca F Turcotte, Ronald T Raines
Feb 5, 2013·Cold Spring Harbor Protocols·Punita KoustubhanMichael Levin
Jun 19, 2008·PloS One·Evelina EdelweissSergey M Deyev
Aug 27, 2009·Biologics : Targets & Therapy·Camillo PortaLuciano Mutti
Apr 26, 2012·Chemical Communications : Chem Comm·Christopher S Theile, Larry W McLaughlin
Aug 3, 2013·Translational Oncology·Thomas J RutkoskiRonald T Raines
Dec 15, 2010·Bioorganic & Medicinal Chemistry Letters·Gregory A EllisRonald T Raines
Oct 15, 2009·European Journal of Pharmacology·Wojciech ArdeltZbigniew Darzynkiewicz
Jun 16, 2009·The FEBS Journal·Rebecca F TurcotteRonald T Raines
Jul 16, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexander A MakarovOlga N Ilinskaya
Jan 6, 2011·The FEBS Journal·Nethaji ThiyagarajanK Ravi Acharya
Aug 29, 2012·The British Journal of Dermatology·V U Emelianov
Oct 22, 2008·Biochemical and Biophysical Research Communications·Rebecca F Turcotte, Ronald T Raines
Oct 11, 2014·Toxicon : Official Journal of the International Society on Toxinology·Azat R GaripovOlga N Ilinskaya
May 17, 2011·Bioorganic & Medicinal Chemistry Letters·Bryan D SmithRonald T Raines
May 26, 2009·Biochimica Et Biophysica Acta·Wan-Cheol Kim, Chow H Lee
Jun 3, 2011·Cancer Biology & Therapy·Thomas J RutkoskiRonald T Raines
Apr 23, 2013·Chemistry & Biology·Michael N LevineRonald T Raines
Jun 29, 2016·Antiviral Research·Thomas HodgeDebra J Taxman
Oct 27, 2015·Cancer Biotherapy & Radiopharmaceuticals·Zuozhao WangFangping Qiu
Mar 1, 2012·Nucleic Acids Research·Irina V NovikovaKarissa Y Sanbonmatsu
Oct 2, 2019·Frontiers in Pharmacology·Nadezhda Mironova, Valentin Vlassov
Mar 9, 2010·Bioorganicheskaia khimiia·S M Deev, E N Labedenko
Feb 11, 2015·Molecular Biotechnology·Marta LualdiFrancesco Acquati

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