Ribonucleoprotein particles: advances and challenges in computational methods

Current Opinion in Structural Biology
Shlomi DvirYael Mandel-Gutfreund


RNA-binding proteins (RBPs) interact with RNA to form Ribonucleoprotein Particles (RNPs). The interaction between RBPs and their RNA partners are traditionally thought to be mediated by highly conserved RNA-binding domains (RBDs). Recently, high-throughput studies led to the discovery of hundreds of novel proteins and domains, of which many do not follow the classical definition of RNA-binding. Despite technological innovations, experimental screenings are currently limited to the detection of specific types of RNPs, underscoring the importance of computational methods for predicting novel RBPs and RNA interacting residues and interfaces. Here, we discuss major challenges in computational prediction of RBPs and RBDs and outline new strategies to circumvent current limitations of experimental techniques.


Mar 15, 2019·PLoS Neglected Tropical Diseases·Rohit ShrivastavaMichal Shapira

Related Concepts

RNA-Binding Motifs
Plasma Protein Binding Capacity
RNA-Binding Proteins
Computational Molecular Biology
Molecular Docking Analysis
RNA Binding
Computed (Procedure)

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