Ribonucleotide reductase inhibitors as anti-herpes agents

Antiviral Research
Stanislaw F Wnuk, Morris J Robins

Abstract

Ribonucleotide reductases (RNRs) supply the 2'-deoxyribonucleotide building blocks for DNA synthesis in mammalian cells and for herpes viruses. The viral-encoded RNRs have unique protein sequences that differ from mammalian enzyme primary structures. Selective inhibition of a viral RNR might provide an approach to new anti-herpes agents with minimal effects on the mammalian host RNRs. This review summarizes efforts to develop anti-herpes agents that selectively target viral-encoded RNRs.

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Citations

Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Fredrik Tholander, Britt-Marie Sjöberg
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Davey SmithSusan Little
Jul 4, 2012·Journal of Veterinary Internal Medicine·M M BrosnahanN Osterrieder
Jul 25, 2012·ACS Chemical Biology·Florian SchmitzbergerPär Nordlund
Apr 8, 2011·The Journal of General Virology·Ricardo MilhoPhilip G Stevenson
Jul 8, 2016·Molecular & Cellular Proteomics : MCP·Paul AshfordMaya Topf
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Oct 9, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Johanna NurboAnders Karlén
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