PMID: 2494656Mar 1, 1989Paper

Ribosomal DNA and Stellate gene copy number variation on the Y chromosome of Drosophila melanogaster

Proceedings of the National Academy of Sciences of the United States of America
E M Lyckegaard, Andrew G Clark

Abstract

Multigene families on the Y chromosome face an unusual array of evolutionary forces. Both ribosomal DNA and Stellate, the two families examined here, have multiple copies of similar sequences on the X and Y chromosomes. Although the rate of sequence divergence on the Y chromosome depends on rates of mutation, gene conversion and exchange with the X chromosome, as well as purifying selection, the regulation of gene copy number may also depend on other pleiotropic functions, such as maintenance of chromosome pairing. Gene copy numbers were estimated for a series of 34 Y chromosome replacement lines using densitometric measurements of slot blots of genomic DNA from adult Drosophila melanogaster. Scans of autoradiographs of the same blots probed with the cloned alcohol dehydrogenase gene, a single copy gene, served as internal standards. Copy numbers span a 6-fold range for ribosomal DNA and a 3-fold range for Stellate DNA. Despite this magnitude of variation, there was no association between copy number and segregation variation of the sex chromosomes.

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Oct 1, 1992·Trends in Genetics : TIG·S M Williams, L G Robbins
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Timothy B SacktonBernardo Lemos
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Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·A K Chippindale, W R Rice
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Sep 3, 2021·Seminars in Cancer Biology·Jurandir Cruz, Bernardo Lemos

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