Ribosomal DNA transcription in dorsal raphe nucleus neurons is increased in residual schizophrenia compared to depressed patients with affective disorders

Psychiatry Research
Marta KrzyżanowskaTomasz Gos

Abstract

The central serotonergic system is implicated differentially in the pathogenesis of depression and schizophrenia. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in both disorders. The study was carried out on paraffin-embedded brains from 27 depressed (15 major depressive disorder, MDD and 12 bipolar disorder, BD) and 17 schizophrenia (9 residual and 8 paranoid) patients and 28 matched controls without mental disorders. The transcriptional activity of ribosomal DNA (rDNA) in DRN neurons was evaluated by the AgNOR silver staining method. A significant effect of diagnosis on rDNA activity was found in the cumulative analysis of all DRN subnuclei. Further analysis revealed an increase in this activity in residual (but not paranoid) schizophrenia compared to depressed (both MDD and BD) patients. The effect was most probably neither confounded by suicide nor related to antidepressant and antipsychotic medication. Our findings suggest that increased activity of rDNA in DRN neurons is a distinct phenomenon in residual schizophrenia, related presumably to differentially disturbed inputs to the DRN and/or their local transformation compared with depressive episodes ...Continue Reading

References

Nov 1, 1992·The International Journal of Neuroscience·R Sandyk
Nov 8, 1990·The Journal of Comparative Neurology·K G BakerI Törk
Oct 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenB Pakkenberg
Oct 2, 1986·The New England Journal of Medicine·U BustoK Sykora
Dec 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·H D Mennel, I Müller
Aug 1, 1997·Mechanisms of Ageing and Development·L M García MorenoJ L Arias
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R L Jakab, P S Goldman-Rakic
Aug 25, 1999·Biological Psychiatry·M D UnderwoodV Arango
Oct 26, 1999·The British Journal of Psychiatry : the Journal of Mental Science·P BolliniC Munizza
Jun 23, 2000·Biological Psychiatry·W Bligh-GloverC A Stockmeier
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·V ArangoJ J Mann
Mar 9, 2002·Psychological Medicine·B BaumannB Bogerts
Apr 5, 2005·Brain Research·Maura BoldriniVictoria Arango
May 12, 2005·Neuropathology and Applied Neurobiology·R M CravenM M Esiri
Sep 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Helene Bach-MizrachiVictoria Arango
Oct 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qunxing DingJeffrey N Keller
Jun 19, 2007·Journal of Psychiatric Research·Maura BoldriniVictoria Arango
Sep 14, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Tomasz GosBernhard Bogerts
Oct 10, 2007·Harvard Review of Psychiatry·W Gordon Frankle
Nov 13, 2007·Trends in Pharmacological Sciences·Trevor SharpPhilip Quérée
Nov 30, 2007·Histochemistry and Cell Biology·Valentina SirriDanièle Hernandez-Verdun
Mar 3, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Maiko HayashidaJun Horiguchi
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Malte WittmannHilmar Bading
Jan 8, 2010·Neurobiology of Disease·Patrick O McGowan, Moshe Szyf
Jun 19, 2010·Nature Reviews. Neuroscience·Okihide Hikosaka
Nov 26, 2010·The Journal of Biological Chemistry·Cynthia GomesMichal Hetman
Mar 23, 2011·Current Opinion in Pharmacology·H Y Meltzer, B W Massey
May 10, 2011·Journal of Chemical Neuroanatomy·Mariano Soiza-Reilly, Kathryn G Commons
Jun 7, 2011·Journal of Chemical Neuroanatomy·Rani K VasudevaBarry D Waterhouse

❮ Previous
Next ❯

Citations

Feb 13, 2016·Genetic Testing and Molecular Biomarkers·Sener TasdemirHasan Turkez
Feb 24, 2017·European Archives of Psychiatry and Clinical Neuroscience·Ralf BrischTomasz Gos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here