Ribosomal protein s6-ps240 is expressed in lesional skin from patients with autoimmune skin blistering diseases

North American Journal of Medical Sciences
Ana Maria Abreu-VelezMichael S Howard

Abstract

The in situ signaling transduction within skin biopsies from patients affected by autoimmune skin blistering diseases is not well-characterized. In autoimmune skin blistering diseases, autoantibodies seem to trigger several intracellular signaling pathways and we investigated the presence of the phosphorylated form of ribosomal protein S6-pS240 within autoimmune skin blistering diseases biopsies. We utilized immunohistochemistry to evaluate the presence of S6-pS240 in lesional skin biopsies of patients affected by autoimmune skin blistering diseases including patients with an endemic and nonendemic pemphigus foliaceus (non EPF), with bullous pemphigoid (BP), pemphigus vulgaris (PV), dermatitis herpetiformis (DH), and the respective controls. Most autoimmune bullous skin diseases biopsies stained positive for S6-pS240 around lesional blisters, including adjacent areas of the epidermis; and within upper dermal inflammatory infiltrates, and/or mesenchymal-endothelial cell junctions within the dermis. We document that S6-pS240 is expressed in lesional areas of skin biopsies from patients with autoimmune skin blistering diseases, as well as on eccrine glands and piloerector muscles. Thus, the role of this molecule in autoimmune skin...Continue Reading

References

May 9, 2006·Trends in Biochemical Sciences·Igor Ruvinsky, Oded Meyuhas
Mar 29, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Volker Spindler, Jens Waschke
Oct 27, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Andrea Kneisel, Michael Hertl
Feb 13, 2013·The British Journal of Dermatology·C BuergerW H Boehncke

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BETA
biopsies
biopsy

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