Ribosomal RNA gene silencing in interpopulation hybrids of Tigriopus californicus: nucleolar dominance in the absence of intergenic spacer subrepeats.

Genetics
Jonathan M Flowers, Ronald S Burton

Abstract

A common feature of interspecific animal and plant hybrids is the uniparental silencing of ribosomal RNA gene transcription, or nucleolar dominance. A leading explanation for the genetic basis of nucleolar dominance in animal hybrids is the enhancer-imbalance model. The model proposes that limiting transcription factors are titrated by a greater number of enhancer-bearing subrepeat elements in the intergenic spacer (IGS) of the dominant cluster of genes. The importance of subrepeats for nucleolar dominance has repeatedly been supported in competition assays between Xenopus laevis and X. borealis minigene constructs injected into oocytes. However, a more general test of the importance of IGS subrepeats for nuclear dominance in vivo has not been conducted. In this report, rRNA gene expression was examined in interpopulation hybrids of the marine copepod Tigriopus californicus. This species offers a rare opportunity to test the role of IGS subrepeats in nucleolar dominance because the internal subrepeat structure, found in the IGS of virtually all animal and plant species, is absent in T. californicus. Our results clearly establish that nucleolar dominance occurs in F1 and F2 interpopulation hybrids of this species. In the F2 gene...Continue Reading

References

Dec 1, 1990·Trends in Genetics : TIG·R H Reeder
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A KuhnI Grummt
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Grimaldi, P P Di Nocera
Nov 1, 1985·The Journal of Cell Biology·R H Reeder
Aug 1, 1984·Cell·R H Reeder, J G Roan
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B D Kohorn, P M Rae
Jan 1, 1980·Annual Review of Biochemistry·E O Long, I B Dawid
Mar 11, 1982·Nature·I GrummtM R Paule
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·R S Burton, B N Lee
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z J ChenC S Pikaard
Nov 14, 2000·Trends in Genetics : TIG·C S Pikaard
Oct 23, 2002·Evolution; International Journal of Organic Evolution·Maarten J Voordouw, Bradley R Anholt
Aug 19, 2003·Nature Reviews. Molecular Cell Biology·Ingrid Grummt, Craig S Pikaard
Dec 1, 1999·Evolution; International Journal of Organic Evolution·Suzanne Edmands
Nov 1, 1990·Evolution; International Journal of Organic Evolution·Ronald S Burton

❮ Previous
Next ❯

Citations

Jul 19, 2013·Plant Cell Reports·Xian-Hong GeZai-Yun Li
Aug 6, 2008·Molecular and Cellular Biology·Danna G EickbushThomas H Eickbush
Dec 30, 2015·The Plant Journal : for Cell and Molecular Biology·Roman MatyášekAleš Kovařík
Apr 19, 2007·Biochimica Et Biophysica Acta·Sasha Preuss, Craig S Pikaard
May 18, 2016·PloS One·Mary Morgan-RichardsSteven A Trewick

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.