Ribosomal RNA pseudouridines and pseudouridine synthases

FEBS Letters
James Ofengand

Abstract

Pseudouridines are found in virtually all ribosomal RNAs but their function is unknown. There are four to eight times more pseudouridines in eukaryotes than in eubacteria. Mapping 19 Haloarcula marismortui pseudouridines on the three-dimensional 50S subunit does not show clustering. In bacteria, specific enzymes choose the site of pseudouridine formation. In eukaryotes, and probably also in archaea, selection and modification is done by a guide RNA-protein complex. No unique specific role for ribosomal pseudouridines has been identified. We propose that pseudouridine's function is as a molecular glue to stabilize required RNA conformations that would otherwise be too flexible.

References

Jul 1, 1977·Nucleic Acids Research·M S Khan, B E Maden
Feb 10, 1976·Biochemistry·R N NazarH Busch
Jan 1, 1990·Progress in Nucleic Acid Research and Molecular Biology·B E Maden
Jul 25, 1985·Nucleic Acids Research·P J ArpsM E Winkler
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·L Johnson, D Söll
Dec 8, 1998·The EMBO Journal·A HenrasM Caizergues-Ferrer
Jul 31, 1999·The Journal of Biological Chemistry·V RamamurthyE G Mueller
Oct 19, 1999·Molecular and Cellular Biology·Y ZebarjadianJ Carbon
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·X GuD V Santi
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·W V NgS DasSarma
Apr 3, 2001·Science·M M YusupovH F Noller
Jun 15, 2001·The Journal of Biological Chemistry·I AnsmantC Branlant
Aug 3, 2001·The Journal of Biological Chemistry·X H LiangS Michaeli
May 24, 2003·Cold Spring Harbor Symposia on Quantitative Biology·J OfengandY Kaya

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Citations

Mar 17, 2005·Chromosoma·U Thomas Meier
Aug 2, 2007·Journal of Structural and Functional Genomics·Allan MatteMiroslaw Cygler
Feb 5, 2013·Bioorganic & Medicinal Chemistry·Moninderpal KaurChristine S Chow
May 12, 2004·Journal of Molecular Biology·Heather C O'FarrellJason P Rife
Sep 6, 2003·Gene·Micheline Fromont-RacineFranco Fasiolo
Sep 1, 2006·Nature·Ling Li, Keqiong Ye
May 30, 2009·Nature Structural & Molecular Biology·Bo LiangHong Li
May 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Akram AlianJanet Finer-Moore
Jul 10, 2008·The Journal of Biological Chemistry·Dorota Piekna-PrzybylskaMaurille J Fournier
Dec 27, 2005·Nucleic Acids Research·Javier Cabello-Villegas, Edward P Nikonowicz
Jun 4, 2005·Nucleic Acids Research·Bruno CharpentierChristiane Branlant
Feb 8, 2007·Nucleic Acids Research·Steve L ReichowGabriele Varani
Sep 15, 2007·Nucleic Acids Research·Osama A YoussefMichael P Terns
Oct 20, 2007·Nucleic Acids Research·Dorota Piekna-PrzybylskaMaurille J Fournier
Jan 11, 2005·Nucleic Acids Research·Shawna L HileyTimothy R Hughes
May 24, 2003·Cold Spring Harbor Symposia on Quantitative Biology·J OfengandY Kaya
Feb 22, 2012·Acta Crystallographica. Section D, Biological Crystallography·Krzysztof BrzezinskiMariusz Jaskolski
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Allan MatteStephen K Burley
Jul 3, 2003·Journal of Bacteriology·Michael S Winters, R A Day
Mar 12, 2008·Molecular and Cellular Biology·Wayne A Decatur, Murray N Schnare
Feb 18, 2003·Molecular and Cellular Biology·Arturas MeskauskasJonathan D Dinman
Jun 17, 2004·Molecular and Cellular Biology·Arnold M KissTamás Kiss
Aug 2, 2005·BMC Molecular Biology·Aivar LiivJaanus Remme
Feb 7, 2007·RNA·Dorota Piekna-PrzybylskaMaurille J Fournier
Mar 24, 2011·Future Medicinal Chemistry·Vincent RoyLuigi A Agrofoglio

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