Ribosomal RNA synthesis and processing in a particulate site in the HeLa cell nucleus
A particulate fraction has been isolated from detergent-prepared HeLa cell nuclei. The fraction consists largely of organelles that resemble the nucleoli of intact cells. The 45S RNA that is precursor to 28S and 18S ribosomal RNA is associated with the fraction. The 32S RNA that is labeled after the 45S RNA and is the apparent precursor to 28S RNA is also associated with the fraction. The nucleoplasm contains 28S RNA that behaves as an intermediate between the 32S nucleolar RNA and the 28S cytoplasmic RNA.
Studies on the specificity and clinical correlation of antiribosomal antibodies in systemic lupus erythematosus sera
Nucleolar DNA in oocytes of crickets: representatives of the subfamilies Oecanthinae and Gryllotalpinae (Orthoptera: Gryllidae)
Ribosome-like granules within areas of the perinuclear space in cells of 13--14 somite chick embryos
The cytoplasmic ribonucleoprotein particles of rat sarcoma cells. I. The particles of ribosomal population and the turnover of their protein moiety
Synthesis of ribosomal RNA during sea urchin development. II. Electrophoretic analysis of nuclear and cytoplasmic RNA's
Studies on the origin of proteins in the nucleoli of mouse ascites tumour cells: a test for protein transfer to the nucleoli
The use of deoxyribonuclease in the isolation of nucleoli and purification of nuclear RNA--a caution
Regulation of DNA-like RNA and the apparent activation of ribosomal RNA synthesis in sea urchin embryos: quantitative measurements of newly synthesized RNA
In vivo interaction of nucleophosmin/B23 and protein C23 during cell cycle progression in HeLa cells
RNA synthesis in cells infected with herpes simplex virus. II. Evidence that a class of viral mRNA is derived from a high molecular weight precursor synthesized in the nucleus
Biochemical studies on adenovirus multiplication, XIX. Resolution of late viral RNA species in the nucleus and cytoplasm
Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: possible evidence for a precursor relationship
Ribonucleoprotein particles in the amphibian oocyte nucleus. Possible intermediates in ribosome synthesis
The regulation of RNA synthesis and processing in the nucleolus during inhibition of protein synthesis
The distribution of the water-soluble inorganic orthophosphate ions within the cell: accumulation in the nucleus. Electron probe microanalysis
A comparison between heterogeneous nuclear RNA and polysomal messenger RNA in HeLa cells by RNA-DNA hybridization
RNA synthesis in HeLa cells. Pattern in hypertonic medium and its similarity to synthesis during G2-prophase
Comparison of the relative synthesis of the proteins of the 50S ribosomal subunit in growing and valine-deprived HeLa cells
RNA synthesis in the ultrastructural and biochemical components of the nucleolus of Chinese hamster ovary cells
Characteristics of nuclear-ribosomal and DNA-like ribonucleic acids differentially extracted by hot-phenol fractionation
Nucleolar chromatin in Chinese hamster ovary cells. Topographical distribution of ribosomal DNA sequences and isolation of ribosomal transcription complexes
Visualization of the joining of ribosomal subunits reveals the presence of 80S ribosomes in the nucleus
RNA synthesis in exponentially growing rat hepatoma cells. I. A caution in equating pulse-labeled polyribosomal RNA with messenger RNA
Ribosome precursor particles in the nucleolus of rat liver. Easily extractable nucleolar 60-S ribonucleoprotein particles and their relation to cytoplasmic large ribosomal subunits
Processing of late adenovirus nuclear RNA to mRNA. Kinetics of formation of intermediates and demonstration that all events are nuclear
Base composition of ribosomal RNA precursors in the HeLa cell nucleolus: further evidence of non-conservative processing
Comparison of regulation of synthesis and utilization of 45S ribosomal precursor RNA in diploid and heteroploid human cells in response to valine deprivation
Localization and kinetics of formation of nuclear heterodisperse RNA, cytoplasmic heterodisperse RNA and polyribosome-associated messenger RNA in HeLa cells
Biosynthesis and distribution of ribosomal particles in the cellular slime mould, Dictyostelium purpureum
Fractionation of heterogeneous nuclear RNA: rates of hybridization and chromosomal distribution of reiterated sequences
Rapid isolation of nucleoli from detergent purified nuclei of various tumor and tissue culture cells
Metabolism of nuclear and cytoplasmic proteins in the visual cortex of sighted rats and rats with retinal degeneration
Studies with the schistosomacide hycanthone: inhibition of macromolecular synthesis and its reversal
Sedimentation properties of the newly synthesized RNA from isolated nuclear components of Chironomus tentans salivary gland cells
Sea urchin embryo chromatin and nuclear ribonucleoproteins fractionated by anion exchange chromatography
The effect of x-radiation on the incorporation of 14C-orotic acid into rapidly labeled nuclear and cytoplasmic RNA
An analysis of the rapidly synthesized ribonucleic acid of the normal human lymphocyte by agarose-polyacrylamide gel electrophoresis
Nuclear metabolism of ribosomal RNA in growing, methionine-limited, and ethionine-treated HeLa cells
Study of RNA in subcellular fractions from rat brain: simultaneous incorporation of [14C]uridine and [3H]methyl-L-methionine
The fine structure of nuclei as revealed by electron microscopy. VI. Relationship between nucleolus formation and sex chromosomes in the type A mouse spermatogonia
RNA-Synthesis in telotrophic meroistic ovarioles of dysdercus intermedius DIST. (heteroptera, pyrrhoc.)
The metabolism of heterogeneous nuclear RNA and the formation of cytoplasmic messenger RNA in animal cells
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Alzheimer's Disease: MS4A
Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.
Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.
Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.
Genetic Screens in iPSC-derived Brain Cells
Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.
This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Pharmacology of Proteinopathies
This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.
Alignment-free Sequence Analysis Tools
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.