Rice Bran Extract Protected against LPS-Induced Neuroinflammation in Mice through Targeting PPAR-γ Nuclear Receptor.

Molecular Neurobiology
May A Abd El FattahOla A Heikal

Abstract

PPAR-γ anti-inflammatory functions have received significant attention since its agonists have been shown to exert a wide range of protective effects in many experimental models of neurologic diseases. Rice bran is very rich in polyunsaturated fatty acids, which are reported to act as PPAR-γ partial agonists. Herein, the anti-inflammatory effect of rice bran extract (RBE) through PPAR-γ activation was evaluated in LPS-induced neuroinflammatory mouse model in comparison to pioglitazone (PG) using 80 Swiss albino mice. RBE (100 mg/kg) and PG (30 mg/kg) were given orally for 21 days and LPS (0.25 mg/kg) was injected intraperitoneally for the last 7 days. TNF-α and COX-2 brain contents were evaluated by real-time PCR and immunohistochemical analysis. In addition, NFκB binding to its response element was evaluated alongside with the effect of treatments on IκB gene expression. Furthermore, PPAR-γ sumoylation was also studied. Finally, histopathological examination was performed for different brain areas. RBE administration was found to protect against the LPS-induced inflammatory effects by decreasing the inflammatory mediator expression in mice brains. It also decreased PPAR-γ sumoylation without significant effect on IκB expressio...Continue Reading

References

Dec 1, 1991·Journal of the American College of Nutrition·C Rukmini, T C Raghuram
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 28, 2002·Science's STKE : Signal Transduction Knowledge Environment·Shamina M Rangwala, Mitchell A Lazar
Jul 16, 2003·European Journal of Pharmacology·Paul AounJames W Simpkins
Aug 29, 2003·Expert Opinion on Investigational Drugs·Anne R Miller, Garret J Etgen
Sep 30, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masashi KitazawaFrank M LaFerla
Jan 3, 2009·Clinical Science·Luis VillacortaY Eugene Chen
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hong Jin LeeNanjoo Suh
Nov 20, 2009·Neurobiology of Aging·Tomohiko SatoToshihiko Iwamoto
Apr 17, 2012·Biochimica Et Biophysica Acta·Z Elizabeth Floyd, Jacqueline M Stephens
May 9, 2012·Phytotherapy Research : PTR·Rebecca M KaupEugen J Verspohl
Sep 19, 2012·Glia·Kaoru SaijoChristopher K Glass
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Olumayokun A OlajideBernd L Fiebich
Aug 2, 2014·Biochemical Pharmacology·Limei WangAtanas G Atanasov
Aug 5, 2015·Nutritional Neuroscience·Stephanie HaglGunter P Eckert
Sep 24, 2015·Journal of Biomedical Science·Mohammad CharkhpourKambiz Hassanzadeh
Oct 6, 2015·PPAR Research·Alice J Kroker, John B Bruning
Jun 16, 2016·Journal of Neuroinflammation·Harsharan S BhatiaBernd L Fiebich
Jul 7, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Haijian SunLiying Qiu
Apr 3, 2019·Nutrients·Wiramon RungratanawanichDaniela Uberti

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Citations

Jun 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tapan BehlSimona Bungau
Aug 28, 2021·International Journal of Molecular Sciences·Pierre LayrolleStéphane Chavanas

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Methods Mentioned

BETA
sumoylation
Protein
ELISA
RNA assay
profiler

Key Resources (RRID) Mentioned

AB_1603934
SCR_003070

Software Mentioned

GraphPad Prism®
GraphPad
Image J

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