Rich-club in the brain's macrostructure: Insights from graph theoretical analysis

Computational and Structural Biotechnology Journal
Dae-Jin Kim, Byoung-Kyong Min

Abstract

The brain is a complex network. Growing evidence supports the critical roles of a set of brain regions within the brain network, known as the brain's cores or hubs. These regions require high energy cost but possess highly efficient neural information transfer in the brain's network and are termed the rich-club. The rich-club of the brain network is essential as it directly regulates functional integration across multiple segregated regions and helps to optimize cognitive processes. Here, we review the recent advances in rich-club organization to address the fundamental roles of the rich-club in the brain and discuss how these core brain regions affect brain development and disorders. We describe the concepts of the rich-club behind network construction in the brain using graph theoretical analysis. We also highlight novel insights based on animal studies related to the rich-club and illustrate how human studies using neuroimaging techniques for brain development and psychiatric/neurological disorders may be relevant to the rich-club phenomenon in the brain network.

References

Nov 4, 1988·Science·P S Churchland, T J Sejnowski
Jun 12, 1998·Nature·D J Watts, S H Strogatz
Jun 4, 1999·Cerebral Cortex·J W ScannellM P Young
Mar 7, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C C HilgetagM P Young
Oct 12, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P J BasserA Aldroubi
Nov 3, 2001·Physical Review Letters·V Latora, M Marchiori
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·M Girvan, M E J Newman
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Aug 21, 2004·Neuroinformatics·Olaf Sporns, Jonathan D Zwi
Sep 8, 2004·Trends in Cognitive Sciences·Olaf SpornsClaus C Hilgetag
Apr 16, 2005·Current Opinion in Neurobiology·Martin I Sereno, Roger B H Tootell
Oct 5, 2005·PLoS Computational Biology·Olaf SpornsRolf Kötter
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·M E J Newman
Dec 21, 2006·The Journal of Comparative Neurology·Mihail Bota, Larry W Swanson
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Oct 18, 2007·PloS One·Olaf SpornsRolf Kötter
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Nov 13, 2008·Physical Review Letters·Tore OpsahlJosé J Ramasco
Feb 20, 2009·The Journal of Comparative Neurology·Frederico A C AzevedoSuzana Herculano-Houzel
Jul 25, 2009·Science·Carter T Butts
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Nov 17, 2009·Frontiers in Human Neuroscience·Suzana Herculano-Houzel
Sep 21, 2010·NeuroImage·Danielle S BassettScott T Grafton
Nov 10, 2010·PloS One·Bernadette C M van WijkAndreas Daffertshofer
Nov 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den HeuvelHilleke E Hulshoff Pol
Dec 7, 2010·Annual Review of Clinical Psychology·Edward T Bullmore, Danielle S Bassett
Feb 10, 2011·PLoS Computational Biology·Lav R VarshneyDmitri B Chklovskii
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Mar 10, 2012·Journal of Cognitive Neuroscience·Caterina GrattonMark D'Esposito
Jan 1, 2011·Brain Connectivity·Karl J Friston
Nov 12, 1986·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J G WhiteS Brenner
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Martijn P van den HeuvelOlaf Sporns
Apr 6, 2013·NeuroImage·Marcel A de Reus, Martijn P van den Heuvel
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emma K TowlsonEdward T Bullmore
Jun 7, 2013·JAMA Psychiatry·Martijn P van den HeuvelRené S Kahn
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nicolas A CrossleyEdward T Bullmore
Aug 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcel A de Reus, Martijn P van den Heuvel

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