Apr 5, 2020

Indomethacin has a potent antiviral activity against SARS CoV-2 in vitro and canine coronavirus in vivo

BioRxiv : the Preprint Server for Biology
Pablo CorderoZ. Zhou


The outbreak of SARS CoV-2 has caused ever increasing attention and public panic all over the world. Currently, there is no specific treatment against the SARS CoV-2. Therefore, identifying effective antiviral agents to combat the disease is urgently needed. Previous studies found that indomethacin has the ability to inhibit the replication of several unrelated DNA and RNA viruses, including SARS-CoV. We found that indomethacin has a directly and potently antiviral activity against the SARS CoV-2 pseudovirus. In canine coronavirus-infected dogs, recovery occurred significantly sooner with symptomatic treatment + oral indomethacin (1 mg/kg body weight) daily treatments than with symptomatic treatment + ribavirin (10-15 mg/kg body weight) daily treatments (P =0.0031), but was not significantly different from that with symptomatic treatment + anti-canine coronavirus serum + canine hemoglobin + canine blood immunoglobulin + interferon treatments (P =0.7784).

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Virus Diseases
RNA, Untranslated
Reconstructive Surgical Procedures
Flavin Mononucleotide
Hairpin Loop Sequence
Protein Biosynthesis
Gene Expression

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Bradley SanvilleStuart Cohen
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Elena SeminariCOVID19 IRCCS San Matteo Pavia Task Force
Nihon rinsho. Japanese journal of clinical medicine
Teruo Kirikae
The New England Journal of Medicine
Qibin Leng, Zvi Bentwich
© 2020 Meta ULC. All rights reserved