RichMind: A Tool for Improved Inference from Large-Scale Neuroimaging Results

PloS One
Adi Maron-KatzRon Shamir


As the use of large-scale data-driven analysis becomes increasingly common, the need for robust methods for interpreting a large number of results increases. To date, neuroimaging attempts to interpret large-scale activity or connectivity results often turn to existing neural mapping based on previous literature. In case of a large number of results, manual selection or percent of overlap with existing maps is frequently used to facilitate interpretation, often without a clear statistical justification. Such methodology holds the risk of reporting false positive results and overlooking additional results. Here, we propose using enrichment analysis for improving the interpretation of large-scale neuroimaging results. We focus on two possible cases: position group analysis, where the identified results are a set of neural positions; and connection group analysis, where the identified results are a set of neural position-pairs (i.e. neural connections). We explore different models for detecting significant overrepresentation of known functional brain annotations using simulated and real data. We implemented our methods in a tool called RichMind, which provides both statistical significance reports and brain visualization. We demon...Continue Reading


Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Jul 27, 2000·Human Brain Mapping·J L LancasterP T Fox
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·M D GreiciusV Menon
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Dec 19, 2003·Nucleic Acids Research·M A HarrisGene Ontology Consortium
Mar 16, 2005·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Joël R PradinesVlado Dancík
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Feb 17, 2007·Bioinformatics·Jelle J Goeman, Peter Bühlmann
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Feb 6, 2010·Nature Protocols·Igor UlitskyRon Shamir
Jul 6, 2010·NeuroImage·Andrew ZaleskyEdward T Bullmore
Mar 4, 2011·Frontiers in Computational Neuroscience·Olaf Sporns
May 28, 2011·Cerebral Cortex·W R ShirerM D Greicius
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Jul 20, 2011·Human Brain Mapping·R Cameron CraddockHelen S Mayberg
May 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lauri NummenmaaMikko Sams
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
Mar 29, 2014·Human Brain Mapping·Chandra SripadaMichael Angstadt
Sep 23, 2014·Journal of Cognitive Neuroscience·Daniel L AmesUri Hasson


Apr 4, 2017·Human Brain Mapping·Eti Ben SimonTalma Hendler

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.