Richter syndrome: A rare complication of chronic lymphocytic leukemia or small lymphocytic lymphoma

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Ewa Wąsik-SzczepanekMarek Hus

Abstract

Richter's syndrome (RS) is a rare complication with an unfavorable prognosis, in which chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) transform into a more aggressive type of lymphoma, most commonly into diffuse large B cell lymphoma (DLBCL) or less often into Hodgkin's lymphoma (HL). The objective of this research paper was to present a retrospective analysis of patients with CLL/SLL whose disease transformed into RS. The study included 217 patients (100 women and 107 men) with CLL/SLL diagnosed in the years 2006-2015 at the Department of Hematooncology and Bone Marrow Transplantation of the Medical University of Lublin, which transformed into RS. We analyzed clinical, laboratory, immunophenotypic (ZAP-70 and CD38 expression), histopathological, and genetic data (del(17p), del(11q)), which was collected at the time of CLL/SLL diagnosis, and some which was collected at the time of transformation. Richter's syndrome was diagnosed in 4.6% of all CLL and SLL patients. The group of patients with RS consisted of 9 patients with primary CLL and 1 patient with a diagnosis of SLL (8 patients with transformation into DLBCL and 2 patients with transformation into HL). Leukemic lymphocytes showed evidence of periph...Continue Reading

Citations

Feb 26, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Silvia Montolio BrevaCarmen Araguás Arasanz

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