Rickets and vitamin D deficiency in Alaska native children

Journal of Pediatric Endocrinology & Metabolism : JPEM
Rosalyn J SingletonJames Tiesinga

Abstract

Rickets and vitamin D deficiency appeared to increase in Alaskan children starting in the 1990s. We evaluated the epidemiology of rickets and vitamin D deficiency in Alaska native (AN) children in 2001-2010. We analyzed 2001-2010 visits with rickets or vitamin D deficiency diagnosis for AN and American Indian children and the general US population aged <10 years. We conducted a case-control study of AN rickets/vitamin D deficient cases and age- and region-matched controls. In AN children, annual rickets-associated hospitalization rate (2.23/100,000 children/year) was higher than the general US rate (1.23; 95% CI 1.08-1.39). Rickets incidence increased with latitude. Rickets/vitamin D deficiency cases were more likely to have malnutrition (OR 38.1; 95% CI 4.9-294), had similar breast-feeding prevalence, and were less likely to have received vitamin D supplementation (OR 0.23; 95% CI 0.1-0.87) than controls. Our findings highlight the importance of latitude, malnutrition, and lack of vitamin D supplementation as risk factors for rickets.

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Citations

May 18, 2016·Journal of Clinical Orthopaedics and Trauma·Tarun ChabraAmrut Raje
Aug 8, 2018·Clinical Practice and Cases in Emergency Medicine·Noopur TripathiAline Baghdassarian
Apr 7, 2018·The Veterinary Record·Tina Kotnik
Oct 26, 2018·American Journal of Public Health·Rosalina D JamesWylie Burke
Mar 15, 2019·Journal of Dental Research·R SingletonJ Berner
Apr 27, 2019·International Journal of Circumpolar Health·Karsten HuefferArleigh Reynolds
May 22, 2019·Paediatrics & Child Health·Maria-Elena LautatzisCelia Rodd
Dec 7, 2016·Paediatrics and International Child Health·Ana L CreoPhilip R Fischer
May 18, 2021·Pediatric Radiology·Maria C Aldana Sierra, Cindy W Christian
Jun 12, 2021·Journal of Bone and Mineral Metabolism·Chong ZhengKewei Li

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