PMID: 6969986Jan 1, 1981Paper

Rickets of prematurity. Supranormal levels of serum 1,25-dihydroxyvitamin D

American Journal of Diseases of Children
R W ChesneyH F DeLuca

Abstract

Rickets, hypocalcemia, hypophosphatemia, and hyperparathyroidism were found in a low-birth-weight premature infant. The concentration of plasma calcitriol (1,25-dihydroxyvitamin D) was 145 pg/mL. With additional exogenous calcitriol (37.5 ng/kg/24 hr) given for eight weeks, the biochemical abnormalities were corrected and healing of rickets was evident. Three months later, while receiving only 400 IU of ergocalciferal daily, the patient had normal levels of serum calcium, phosphate, and alkaline phosphatase with a serum calcitriol concentration of 36 pg/mL. These observations suggest that rickets of prematurity may involve a malabsorption of calcium and phosphorus with an elevated calcitriol level needed to overcome this inadequate absorption. Additional doses of calcitriol may be of benefit in these infants, although it must be given carefully. Furthermore, the role of phosphate supplementation in these infants requires consideration.

Citations

Jul 1, 1985·Archives of Disease in Childhood·O G Brooke, A Lucas
Aug 1, 1983·Archives of Disease in Childhood·O G Brooke
Oct 1, 1982·Archives of Disease in Childhood·I Z KovarJ Wallis
Feb 1, 1986·Australian Dental Journal·W K Seow
Mar 1, 1983·Clinics in Endocrinology and Metabolism·A M Spiegel, S J Marx
Sep 1, 1983·Acta paediatrica Scandinavica·T MarkestadD Aarskog
Jul 1, 1983·Acta paediatrica Scandinavica·T MarkestadD Aarskog
Sep 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·J S BertinoT C Halpin
Apr 1, 1993·Calcified Tissue International·B SchröderJ Harmeyer
Nov 1, 1982·Archives of Disease in Childhood·N McIntoshO G Brooke
May 1, 1985·Calcified Tissue International·L S HillmanS Dokoh
Dec 1, 1981·Australian Paediatric Journal·G J CleghornJ P Masel
Jan 1, 1989·Journal of the American College of Nutrition·W C Heird
Jan 1, 1994·Bone·N BeyersS F Hough

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